Elacestrant dihydrochloride - CAS 1349723-93-8 (HCl)

Elacestrant , also known as RAD1901, is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM), with potential antineoplastic and estrogen-like activities. Upon oral administration of higher doses of RAD1901, this agent acts as a SERD, which binds to the estrogen receptor (ER) and induces a conformational change that results in the degradation of the receptor. This may inhibit the growth and survival of ER-expressing cancer cells. At lower doses of this agent, RAD1901 acts as a SERM and has estrogen-like effects in certain tissues, which can both reduce hot flashes and protect against bone loss. In addition, RAD1901 is able to cross the blood-brain barrier (BBB).

Catalog Number: I006453

CAS Number: 1349723-93-8 (HCl)

Molecular Formula: C30H40Cl2N2O2

Molecular Weight:531.56

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsRAD1901; RAD-1901; RAD 1901; RAD1901 HCl salt; Elacestrant dihydrochloride;(R)-6-(2-(ethyl(4-(2-(ethylamino)ethyl)benzyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol dihydrochloride

Property

Molecular Formula: C30H40Cl2N2O2
Molecular Weight531.56
SolubilitySoluble in DMSO, not in water
Purity≥95%
Storage0 - 4°C for short term or -20 °C for long term

Computed Descriptor

InChIInChI=1S/C30H38N2O2.2ClH/c1-4-31-17-16-22-6-8-23(9-7-22)21-32(5-2)30-20-28(34-3)14-15-29(30)26-11-10-25-19-27(33)13-12-24(25)18-26;;/h6-9,12-15,19-20,26,31,33H,4-5,10-11,16-18,21H2,1-3H3;2*1H/t26-;;/m1../s1
InChIKeyXGFHYCAZOCBCRQ-FBHGDYMESA-N
SMILESOC1=CC=C2C[C@H](C3=CC=C(OC)C=C3N(CC4=CC=C(CCNCC)C=C4)CC)CCC2=C1.[H]Cl.[H]Cl