PIM-447 dihydrochloride

• CAT Number: I002363
• CAS Number: 1820565-69-2
• Molecular Formula: C24H25Cl2F3N4O
• Molecular Weight: 513.38
• Purity: ≥95%
• Target: target: pan-PIM inhibitor [2] [3]
• Solubility: DMSO ≥ 50 mg/mL
• Storage: Store at -20°C

PIM-447 dihydrochloride (Cat.No:I002363) is a selective inhibitor of PIM kinases, a family of serine/threonine kinases implicated in various cancers. PIM-447 has demonstrated potent antitumor activity by inhibiting cancer cell proliferation and promoting apoptosis. It is being studied for its therapeutic potential in hematological malignancies and solid tumors in preclinical and clinical settings.

Reference

[1]. Paíno T et al. The novel pan-PIM kinase inhibitor, PIM447, displays dual anti-myeloma and bone protective effects, and potently synergizes with current standards of care. Clin Cancer Res. 2016 Jul 20.

[2]. Burger MT et al. Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.
J Med Chem. 2015 Nov 12;58(21):8373-86.

[3]. Peters TL et al. Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447.
Oncotarget. 2016 Aug 20