EHT 1864

• CAT Number: I004789
• CAS Number: 754240-09-0
• Molecular Formula: C25H27F3N2O4S • 2HCl
• Molecular Weight: 581.5
• Purity: ≥95%
• Target: Amyloid β
• Solubility: DMSO: ≥ 38 mg/mL
• Storage: Store at -20°C
• InChIKey: LSECOAJFCKFQJG-UHFFFAOYSA-N

EHT 1864（Cat No.:I004789） is a highly potent inhibitor of Rac family GTPases, with dissociation constants (Kd) of 40 nM, 50 nM, 60 nM, and 250 nM for Rac1, Rac1b, Rac2, and Rac3, respectively. Rac GTPases are crucial regulators of various cellular processes, including cytoskeletal reorganization and cell migration. By selectively inhibiting different Rac isoforms, EHT 1864 disrupts their signaling pathways, which may have implications in cancer, inflammation, and other diseases associated with aberrant Rac activity. The high affinity and specificity of EHT 1864 make it a valuable tool for studying Rac GTPase function and potential therapeutic interventions.

Reference

[1]. Desire L, et al. RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo. J Biol Chem. 2005 Nov 11;280(45):37516-25.
[2]. Shutes A, et al. Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J Biol Chem. 2007 Dec 7;282(49):35666-78.
[3]. Onesto C, et al. Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. Methods Enzymol. 2008;439:111-29.