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EHNA hydrochloride

EHNA hydrochloride

  • CAT Number: R004066
  • CAS Number: 58337-38-5
  • Molecular Formula: C₁₄H₂₃N₅O ∙ HCl
  • Molecular Weight: 313.83
  • Purity: ≥95%
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EHNA is a reversible adenosine deaminase inhibitor (IC<sub>50</sub> = 1.2 μM in human red blood cells) that also selectively inhibits the cGMP-<wbr></wbr>specific phosphodiesterase (PDE2) (IC<sub>50</sub>s = 0.8 and 2 μM from human and porcine myocardium, respectively, 3.5 μM in rat hepatocyte, and 5.5 μM in human platelet). Comparatively, EHNA is much less potent at inhibiting PDE1, PDE3, or PDE4 (IC<sub>50</sub>s &gt; 100 μM). EHNA has been used to evaluate cardioprotective and neuroprotective effects during ischemia, to study the role of cAMP/cGMP signaling, and to maintain pluripotency/prevent differentiation of human embryonic stem cells.

Catalog Number R004066
CAS Number 58337-38-5
Molecular Formula

C₁₄H₂₃N₅O ∙ HCl

Purity 95%
Storage -20°C
InChI InChI=1S/C14H23N5O.ClH/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19;/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17);1H/t10-,11+;/m1./s1
InChIKey VVDXNJRUNJMYOZ-DHXVBOOMSA-N
SMILES CCCCCCC(C(C)O)N1C=NC2=C1N=CN=C2N.Cl

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