EGFR-IN-1 TFA

• CAT Number: I045783
• CAS Number: 2753348-63-7
• Molecular Formula: C30H31F3N6O6
• Molecular Weight: 628.60
• Purity: ≥95%
• Synonyms: N-[3-[2-[4-[2-(dimethylamino)ethoxy]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C28H30N6O4.C2HF3O2/c1-6-25(35)30-19-8-7-9-20(15-19)34-26(36)14-18(2)22-17-29-28(32-27(22)34)31-23-11-10-21(16-24(23)37-5)38-13-12-33(3)4;3-2(4,5)1(6)7/h6-11,14-17H,1,12-13H2,2-5H3,(H,30,35)(H,29,31,32);(H,6,7)
• InChIKey: YXUXRIRLHPSVTF-UHFFFAOYSA-N
• SMILES: CC1=CC(=O)N(C2=NC(=NC=C12)NC3=C(C=C(C=C3)OCCN(C)C)OC)C4=CC=CC(=C4)NC(=O)C=C.C(=O)(C(F)(F)F)O

EGFR-IN-1 TFA（Cat No.:I045783）is a potent, selective inhibitor of epidermal growth factor receptor (EGFR) kinase, a critical driver of tumor growth, survival, and metastasis in various cancers. By targeting EGFR signaling, this compound suppresses downstream pathways such as PI3K/AKT and MAPK, leading to reduced proliferation and enhanced apoptosis in cancer cells. The trifluoroacetate (TFA) salt improves solubility and handling, making it suitable for laboratory use. EGFR-IN-1 TFA is a valuable research tool for studying oncogenic signaling, resistance mechanisms, and the development of targeted therapies in cancer biology.