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Eeyarestatin I

Eeyarestatin I

  • CAT Number: I010853
  • CAS Number: 412960-54-4
  • Molecular Formula: C₂₇H₂₅Cl₂N₇O₇
  • Molecular Weight: 630.44
  • Purity: ≥95%
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Potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA.

Catalog Number I010853
CAS Number 412960-54-4
Molecular Formula

C₂₇H₂₅Cl₂N₇O₇

Purity 95%
Solubility Soluble to 100 mM in DMSO
Storage Desiccate at +4C
InChI InChI=1S/C27H25Cl2N7O7/c1-27(2)24(35(40)25(38)31-19-9-5-17(28)6-10-19)34(20-11-7-18(29)8-12-20)26(39)33(27)16-22(37)32-30-15-3-4-21-13-14-23(43-21)36(41)42/h3-15,24,40H,16H2,1-2H3,(H,31,38)(H,32,37)/b4-3+,30-15+
InChIKey JTUXTPWYZXWOIB-LWWHHIEBSA-N
SMILES CC1(C(N(C(=O)N1CC(=O)NN=CC=CC2=CC=C(O2)[N+](=O)[O-])C3=CC=C(C=C3)Cl)N(C(=O)NC4=CC=C(C=C4)Cl)O)C

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