For research use only. Not for therapeutic Use.
EEDi-5285（Cat No.:I026725）is a potent and selective small-molecule inhibitor of embryonic ectoderm development (EED), a core component of the Polycomb Repressive Complex 2 (PRC2), which mediates epigenetic silencing through trimethylation of histone H3 at lysine 27 (H3K27me3). By disrupting the EED–EZH2 interaction, EEDi-5285 inhibits PRC2 activity, leading to derepression of tumor suppressor genes and impaired cancer cell proliferation. It has shown strong antitumor effects in preclinical models, particularly in malignancies with PRC2 dependence. EEDi-5285 represents a novel epigenetic therapy targeting transcriptional repression in cancer and developmental disorders.
| CAS Number | 2488952-40-3 |
| Synonyms | 8-(6-cyclopropylpyridin-3-yl)-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-1-methylsulfonylimidazo[1,5-c]pyrimidin-5-amine |
| Molecular Formula | C24H22FN5O3S |
| Purity | ≥95% |
| IUPAC Name | 8-(6-cyclopropylpyridin-3-yl)-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-1-methylsulfonylimidazo[1,5-c]pyrimidin-5-amine |
| InChI | InChI=1S/C24H22FN5O3S/c1-34(31,32)23-22-17(15-4-6-20(26-10-15)14-2-3-14)11-27-24(30(22)13-29-23)28-12-18-16-8-9-33-21(16)7-5-19(18)25/h4-7,10-11,13-14H,2-3,8-9,12H2,1H3,(H,27,28) |
| InChIKey | BMLWIABJRSYZDK-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)C1=C2C(=CN=C(N2C=N1)NCC3=C(C=CC4=C3CCO4)F)C5=CN=C(C=C5)C6CC6 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
