For research use only. Not for therapeutic Use.
EED226-COOH（Cat No.:I015521）is a carboxyl-functionalized derivative of EED226, a potent, selective allosteric inhibitor of the Polycomb Repressive Complex 2 (PRC2) subunit EED. By binding to EED, it disrupts PRC2’s ability to methylate histone H3 at lysine 27 (H3K27me3), leading to transcriptional reprogramming and derepression of silenced genes. The carboxyl group enables conjugation for probe development, biotinylation, or linker attachment in chemical biology applications. EED226-COOH is valuable for exploring epigenetic regulation, cancer biology, and PROTAC design, providing researchers with a versatile tool for studying PRC2-mediated transcriptional control.
| CAS Number | 2467965-71-3 |
| Synonyms | 4-[5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl]benzoic acid |
| Molecular Formula | C17H13N5O3 |
| Purity | ≥95% |
| IUPAC Name | 4-[5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl]benzoic acid |
| InChI | InChI=1S/C17H13N5O3/c23-16(24)12-5-3-11(4-6-12)14-9-19-17(22-10-20-21-15(14)22)18-8-13-2-1-7-25-13/h1-7,9-10H,8H2,(H,18,19)(H,23,24) |
| InChIKey | MTAJESLOWNUVMU-UHFFFAOYSA-N |
| SMILES | C1=COC(=C1)CNC2=NC=C(C3=NN=CN32)C4=CC=C(C=C4)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
