Edrophonium chloride

• CAT Number: I000590
• CAS Number: 116-38-1
• Molecular Formula: C10H16NO • Cl
• Molecular Weight: 201.69
• Purity: ≥95%
• Target: AChE
• Solubility: DMSO: 31 mg/mL
• Storage: Store at -20°C
• IUPAC Name: ethyl-(3-hydroxyphenyl)-dimethylazanium;chloride
• InChI: InChI=1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H
• InChIKey: BXKDSDJJOVIHMX-UHFFFAOYSA-N
• SMILES: CC[N+](C)(C)C1=CC(=CC=C1)O.[Cl-]

Edrophonium chloride (Cat.No:I000590) is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.

Reference

1:Upper eyelid retraction disclosed after edrophonium chloride administration in a patient with Graves/’ orbitopathy and myasthenia gravis. Kang H, Takahashi Y, Iwaki M, Asamura S, Kakizaki H.Clin Ophthalmol. 2012;6:807-10. doi: 10.2147/OPTH.S29408. Epub 2012 May 28. PMID: 22701081 Free PMC Article2:The effect of cholinergic enhancement during filling cystometry: can edrophonium chloride be used as a provocative test for overactive bladder? Yossepowitch O, Gillon G, Baniel J, Engelstein D, Livne PM.J Urol. 2001 May;165(5):1441-5. PMID: 11342893 3:[Edrophonium chloride (Tensilon) test: a safe method in diagnosing myasthenia gravis]. Domanovits H, Wenger S, Schillinger M, Mayr N, Holzer M, Laggner AN, Zeitlhofer J.Wien Klin Wochenschr. 2000 Jul 7;112(13):592-5. German. PMID: 10944818 4:The effect of edrophonium chloride on muscle balance in normal subjects and those with nonmyasthenic strabismus. Siatkowski RM, Shah L, Feuer WJ.J Neuroophthalmol. 1997 Mar;17(1):7-11. PMID: 9093954 5:The effect of edrophonium chloride-induced chest pain on esophageal blood flow and motility. Gustafsson U, Tibbling L.Scand J Gastroenterol. 1997 Feb;32(2):104-7. PMID: 9051868 6:Edrophonium chloride for testing colonic contractile activity in man. Bassotti G, Imbimbo BP, Betti C, Erbella GS, Pelli MA, Morelli A.Acta Physiol Scand. 1991 Mar;141(3):289-93. PMID: 1858502 7:Esophageal chest pain. Value of high-dose provocative testing with edrophonium chloride in patients with normal esophageal manometries. Lee CA, Reynolds JC, Ouyang A, Baker L, Cohen S.Dig Dis Sci. 1987 Jul;32(7):682-8. PMID: 3595381 8:Myasthenia gravis: protective effect of ipratropiumbromide (Atrovent) on airways obstruction caused by edrophonium chloride (Tensilon). Szathmáry I, Magyar P, Szobor A.Eur Neurol. 1981;20(1):56-61. PMID: 6451430 9:Determination of edrophonium chloride injection USP in the presence of preservatives. Hamill TW.J Assoc Off Anal Chem. 1979 Sep;62(5):1110-2. PMID: 528457 10:Myasthenia gravis: lung-function studies without and with edrophonium chloride. Magyar P, Szathmáry I, Szobor A.Eur Neurol. 1979;18(1):59-65. PMID: 436864