Edoxaban M4

• CAT Number: I014312
• CAS Number: 834919-19-6
• Molecular Formula: C22H25ClN6O5S
• Molecular Weight: 520.99
• Purity: ≥95%
• Synonyms: (1S,3R,4S)-4-[[2-[(5-chloropyridin-2-yl)amino]-2-oxoacetyl]amino]-3-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexane-1-carboxylic acid
• InChI: InChI=1S/C22H25ClN6O5S/c1-29-7-6-14-16(10-29)35-21(27-14)20(32)26-15-8-11(22(33)34)2-4-13(15)25-18(30)19(31)28-17-5-3-12(23)9-24-17/h3,5,9,11,13,15H,2,4,6-8,10H2,1H3,(H,25,30)(H,26,32)(H,33,34)(H,24,28,31)/t11-,13-,15+/m0/s1
• InChIKey: QPYMJNYAASVNAP-CORIIIEPSA-N
• SMILES: CN1CCC2=C(C1)SC(=N2)C(=O)NC3CC(CCC3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)O

Edoxaban M4 (Cat No.: I014312) is the major active metabolite of Edoxaban, a direct oral factor Xa inhibitor used as an anticoagulant. M4 retains pharmacological activity by selectively inhibiting factor Xa, thereby preventing thrombin generation and reducing clot formation. It arises primarily through hepatic metabolism of Edoxaban and contributes to its overall therapeutic profile. Edoxaban M4 is utilized in pharmacokinetic, metabolic, and drug safety studies, serving as a reference standard for understanding metabolism, bioavailability, and anticoagulant mechanisms in preclinical and clinical research.

Reference

[1]. Romain Siriez, et al. Importance of measuring pharmacologically active metabolites of edoxaban: development and validation of an ultra-high-performance liquid chromatography coupled with a tandem mass spectrometry method. J Thromb Thrombolysis. 2020 Apr;4
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[2]. Kathrin I Foerster, et al. Simultaneous quantification of direct oral anticoagulants currently used in anticoagulation therapy. J Pharm Biomed Anal. 2018 Jan 30;148:238-244.
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