Edaravone

• CAT Number: A000382
• CAS Number: 89-25-8
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.2
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 5-methyl-2-phenyl-4H-pyrazol-3-one
• InChI: InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
• InChIKey: QELUYTUMUWHWMC-UHFFFAOYSA-N
• SMILES: CC1=NN(C(=O)C1)C2=CC=CC=C2

Edaravone（Cat No.:A000382）, is a neuroprotective drug used in the treatment of certain neurological conditions. It is particularly recognized for its use in amyotrophic lateral sclerosis (ALS) and acute ischemic stroke. Edaravone functions as a free radical scavenger, helping to mitigate oxidative stress and cellular damage in the nervous system. By reducing oxidative damage, it may slow the progression of ALS or aid in stroke recovery.

Reference

1: Wang X, Lai R, Su X, Chen G, Liang Z. Edaravone attenuates
lipopolysaccharide-induced acute respiratory distress syndrome associated early
pulmonary fibrosis via inhibition of oxidative stress and transforming growth
factor-β1/Smad3 signaling. Biochem Biophys Res Commun. 2017 Nov 1. pii:
S0006-291X(17)32152-6. doi: 10.1016/j.bbrc.2017.10.165. [Epub ahead of print]
PubMed PMID: 29102631.

2: Rothstein JD. Edaravone: A new drug approved for ALS. Cell. 2017 Nov
2;171(4):725. doi: 10.1016/j.cell.2017.10.011. PubMed PMID: 29100067.

3: Zhang WW, Bai F, Wang J, Zheng RH, Yang LW, James EA, Zhao ZQ. Edaravone
inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing
expression of angiotensin II AT1 receptor. Drug Des Devel Ther. 2017 Oct
16;11:3019-3033. doi: 10.2147/DDDT.S144807. eCollection 2017. PubMed PMID:
29081650; PubMed Central PMCID: PMC5652925.

4: Xu YP, Han F, Tan J. Edaravone protects the retina against
ischemia/reperfusion‑induced oxidative injury through the PI3K/Akt/Nrf2 pathway.
Mol Med Rep. 2017 Oct 6. doi: 10.3892/mmr.2017.7739. [Epub ahead of print] PubMed
PMID: 29039497.

5: Zhang X, Xu F, Liu L, Feng L, Wu X, Shen Y, Sun Y, Wu X, Xu Q. (+)-Borneol
improves the efficacy of edaravone against DSS-induced colitis by promoting M2
macrophages polarization via JAK2-STAT3 signaling pathway. Int Immunopharmacol.
2017 Dec;53:1-10. doi: 10.1016/j.intimp.2017.10.002. Epub 2017 Oct 10. PubMed
PMID: 29028547.

6: Wang HM, Zhang T, Huang JK, Xiang JY, Chen JJ, Fu JL, Zhao YW. Edaravone
Attenuates the Proinflammatory Response in Amyloid-β-Treated Microglia by
Inhibiting NLRP3 Inflammasome-Mediated IL-1β Secretion. Cell Physiol Biochem.
2017 Oct 5;43(3):1113-1125. doi: 10.1159/000481753. [Epub ahead of print] PubMed
PMID: 28977782.

7: Al-Chalabi A, Andersen PM, Chandran S, Chio A, Corcia P, Couratier P,
Danielsson O, de Carvalho M, Desnuelle C, Grehl T, Grosskreutz J, Holmøy T, Ingre
C, Karlsborg M, Kleveland G, Koch JC, Koritnik B, KuzmaKozakiewicz M, Laaksovirta
H, Ludolph A, McDermott C, Meyer T, Mitre Ropero B, Mora Pardina J, Nygren I,
Petri S, Povedano Panades M, Salachas F, Shaw P, Silani V, Staaf G, Svenstrup K,
Talbot K, Tysnes OB, Van Damme P, van der Kooi A, Weber M, Weydt P, Wolf J,
Hardiman O, van den Berg LH. July 2017 ENCALS statement on edaravone. Amyotroph
Lateral Scler Frontotemporal Degener. 2017 Nov;18(7-8):471-474. doi:
10.1080/21678421.2017.1369125. Epub 2017 Oct 4. PubMed PMID: 28975816.

8: Akiyama G, Azuchi Y, Guo X, Noro T, Kimura A, Harada C, Namekata K, Harada T.
Edaravone Prevents Retinal Degeneration in Adult Mice Following Optic Nerve
Injury. Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4908-4914. doi:
10.1167/iovs.17-22250. PubMed PMID: 28973341.

9: Kapoor S. Edaravone and Its Protective Effects against Disease Progression in
Neurological Conditions Besides Strokes. J Stroke Cerebrovasc Dis. 2017 Sep 27.
pii: S1052-3057(17)30463-9. doi: 10.1016/j.jstrokecerebrovasdis.2017.08.042.
[Epub ahead of print] PubMed PMID: 28964649.

10: Lin H, Ma X, Wang BC, Zhao L, Liu JX, Pu FF, Hu YQ, Hu HZ, Shao ZW. Edaravone
ameliorates compression-induced damage in rat nucleus pulposus cells. Life Sci.
2017 Nov 15;189:76-83. doi: 10.1016/j.lfs.2017.09.024. Epub 2017 Sep 20. PubMed
PMID: 28942283.