Edaglitazone

• CAT Number: I006587
• CAS Number: 213411-83-7
• Molecular Formula: C24H20N2O4S2
• Molecular Weight: 464.56
• Purity: ≥95%
• Synonyms: 5-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl]methyl]-1,3-thiazolidine-2,4-dione
• InChI: InChI=1S/C24H20N2O4S2/c1-14-18(25-23(30-14)15-5-3-2-4-6-15)9-11-29-19-8-7-16(21-17(19)10-12-31-21)13-20-22(27)26-24(28)32-20/h2-8,10,12,20H,9,11,13H2,1H3,(H,26,27,28)
• InChIKey: HAAXAFNSRADSMK-UHFFFAOYSA-N
• SMILES: CC1=C(N=C(O1)C2=CC=CC=C2)CCOC3=C4C=CSC4=C(C=C3)CC5C(=O)NC(=O)S5

Edaglitazone (Cat No.: I006587) is a synthetic thiazolidinedione (TZD) compound that functions as a potent agonist of peroxisome proliferator-activated receptor gamma (PPARγ). By activating this nuclear receptor, edaglitazone enhances insulin sensitivity, regulates glucose metabolism, and improves lipid profiles, making it a candidate for type 2 diabetes research. It has been investigated for its effects on adipogenesis, inflammation, and metabolic homeostasis. Although not widely developed for clinical application, edaglitazone remains a valuable research compound in endocrinology and metabolic disease studies, supporting drug discovery efforts.

Reference

[1]. Dietz M, et, al. Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors. ChemMedChem. 2012 Jun;7(6):1101-11.
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[2]. Fürnsinn C, et, al. Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism. Br J Pharmacol. 1999 Nov;128(6):1141-8.
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[3]. Muñoz-Gutiérrez C, et, al. Study of the interactions between Edaglitazone and Ciglitazone with PPARγ and their antiplatelet profile. Life Sci. 2017 Oct 1;186:59-65.
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