Ecabet Sodium

• CAT Number: I006582
• CAS Number: 86408-72-2
• Molecular Formula: C20H27NaO5S
• Molecular Weight: 402.481
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: sodium;(4bS,8R,8aR)-8-carboxy-4b,8-dimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenanthrene-3-sulfonate
• InChI: InChI=1S/C20H28O5S.Na/c1-12(2)14-10-13-6-7-17-19(3,8-5-9-20(17,4)18(21)22)15(13)11-16(14)26(23,24)25;/h10-12,17H,5-9H2,1-4H3,(H,21,22)(H,23,24,25);/q;+1/p-1/t17-,19-,20-;/m1./s1
• InChIKey: RCVIHORGZULVTN-YGJXXQMASA-M
• SMILES: CC(C)C1=C(C=C2C(=C1)CCC3C2(CCCC3(C)C(=O)O)C)S(=O)(=O)[O-].[Na+]

Ecabet Sodium is a prescription eye drop for the treatment of dry eye syndrome. It is a new class of molecules that increases the quantity and quality of mucin produced by conjunctival goblet cells and corneal epithelia. Mucin is a glycoprotein component of tear film that lubricates while retarding moisture loss from tear evaporation. Ecabet Sodium is currently marketed in Japan as an oral agent for treatment of gastric ulcers and gastritis.

Reference

1:Ecabet sodium alleviates neomycin-induced hair cell damage. Rah YC, Choi J, Yoo MH, Yum G, Park S, Oh KH, Lee SH, Kwon SY, Cho SH, Kim S, Park HC.Free Radic Biol Med. 2015 Dec;89:1176-83. doi: 10.1016/j.freeradbiomed.2015.11.007. Epub 2015 Nov 10. PMID: 26561773 2:The effect of sequential therapy with lansoprazole and ecabet sodium in treating iatrogenic gastric ulcer after endoscopic submucosal dissection: a randomized prospective study. Ahn JY, Choi CH, Lee JW, Park SJ, Kim JW, Chang SK, Han SB.J Dig Dis. 2015 Feb;16(2):75-82. doi: 10.1111/1751-2980.12214. PMID: 25420889 3:Efficacy and safety of ecabet sodium as an adjuvant therapy for Helicobacter pylori eradication: a systematic review and meta-analysis. Wang Y, Wang B, Lv ZF, Yang Y, Wang F, Wang H, Chen S, Xie Y, Zhou X.Helicobacter. 2014 Oct;19(5):372-81. doi: 10.1111/hel.12136. Epub 2014 May 14. Review. PMID: 24826809 4:Efficacy of gastro-retentive forms of ecabet sodium in the treatment of gastric ulcer in rats. Kim JY, Bae HJ, Choi J, Lim JR, Kim SW, Lee SH, Park ES.Arch Pharm Res. 2014 Aug;37(8):1053-62. doi: 10.1007/s12272-013-0278-0. Epub 2013 Nov 20. PMID: 24254934 5:Helicobacter pylori eradication with ecabet sodium, omeprazole, amoxicillin, and clarithromycin versus bismuth, omeprazole, amoxicillin, and clarithromycin quadruple therapy: a randomized, open-label, phase IV trial. Liang J, Li J, Han Y, Xia J, Yang Y, Li W, Zhang S, Wu Y, Yuan Y, Li Z, Du Y, Chen M, Chen B, Jiang B, Bai Y, Wen Q, Wu K, Fan D.Helicobacter. 2012 Dec;17(6):458-65. doi: 10.1111/j.1523-5378.2012.00971.x. Epub 2012 Jul 2. PMID: 23066868 6:Effect of ecabet sodium treatment on urea breath test and stool antigen tests in volunteers with Helicobacter pylori infection. Okuda M, Yamamoto N, Fukuda N, Maekawa K, Kusaka T, Hashimoto M, Kotake J, Koizuka H, Fukuda Y.J Gastroenterol Hepatol. 2012 Apr;27 Suppl 3:100-2. doi: 10.1111/j.1440-1746.2012.07080.x. PMID: 22486880 7:Triple therapy with ecabet sodium, amoxicillin and lansoprazole for 2 weeks as the rescue regimen for H. pylori infection. Furuta T, Kato M, Sugimoto M, Sasaki M, Kamoshida T, Furukawa K, Inaba T, Tomita T, Shirai T, Ishii N, Nomura H, Konda Y, Asaka M; Japan Gast Study Group..Intern Med. 2011;50(5):369-74. Epub 2011 Mar 1. PMID: 21372444 Free Article8:Efficacy of ecabet sodium enema on intractable rectal ulcer after piecemeal endoscopic mucosal resection for rectal tumor. Yoshioka K, Ueno Y, Tanaka S, Nagai K, Onitake T, Hanaoka R, Chayama K.Clin J Gastroenterol. 2010 Dec;3(6):285-8. doi: 10.1007/s12328-010-0174-9. Epub 2010 Sep 17. PMID: 26190485 9:Quadruple therapy with ecabet sodium, omeprazole, amoxicillin and metronidazole is effective for eradication of Helicobacter pylori after failure of first-line therapy (KDOG0201 Study). Koizumi W, Tanabe S, Nakatani K, Ishido K, Nishimura K, Azuma M, Ae T, Sasaki T, Higuchi K, Katada C, Nakayama N, Saigenji K.J Clin Pharm Ther. 2010 Jun;35(3):303-7. doi: 10.1111/j.1365-2710.2009.01092.x. PMID: 20831531 10:Ecabet sodium promotes the healing of trinitrobenzene-sulfonic-acid-induced ulceration by enhanced restitution of intestinal epithelial cells. Takagi T, Naito Y, Okuda T, Uchiyama K, Adachi S, Mizushima K, Handa O, Kokura S, Ichikawa H, Yoshikawa T.J Gastroenterol Hepatol. 2010 Jul;25(7):1259-65. doi: 10.1111/j.1440-1746.2010.06263.x. PMID: 20594253