(E)-Flavokawain A

• CAT Number: I018420
• CAS Number: 37951-13-6
• Molecular Formula: C₁₈H₁₈O₅
• Molecular Weight: 314.33
• Purity: ≥95%
• Storage: 4°C, protect from light
• IUPAC Name: (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
• InChI: InChI=1S/C18H18O5/c1-21-13-7-4-12(5-8-13)6-9-15(19)18-16(20)10-14(22-2)11-17(18)23-3/h4-11,20H,1-3H3/b9-6+
• InChIKey: CGIBCVBDFUTMPT-RMKNXTFCSA-N
• SMILES: COC1=CC=C(C=C1)C=CC(=O)C2=C(C=C(C=C2OC)OC)O

(E)-Flavokawain A (Cat No.:I018420) is a chalcone extracted from Kava pepper, which has anticancer effects. (E)-Flavokawain A induces apoptosis of bladder cancer cells and inhibits tumor growth in mice by intervening in bax protein-dependent and mitochondria-dependent apoptotic pathways.

Reference

[1]. Zi X, et al. Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. Cancer Res. 2005 Apr 15;65(8):3479-86.