(E)-Akt inhibitor-IV

• CAT Number: I021685
• CAS Number: 959841-49-7
• Molecular Formula: C31H27IN4S
• Molecular Weight: 614.54
• Purity: ≥95%

(E)-Akt Inhibitor IV（Cat No.:I021685）is a selective allosteric inhibitor of Akt (protein kinase B), a key regulator of cell survival, metabolism, and proliferation. This compound targets the inactive conformation of Akt1 and Akt2, preventing their membrane translocation and phosphorylation. It shows potent antiproliferative effects in cancer models where Akt is hyperactivated, such as PTEN-deficient or PI3K-mutant cells. By blocking downstream signaling pathways like mTOR, (E)-Akt Inhibitor IV helps elucidate Akt’s role in tumor progression and resistance mechanisms, making it a valuable tool for oncology and cell signaling research.