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Duocarmycin TM

Duocarmycin TM

  • CAT Number: I019771
  • CAS Number: 157922-77-5
  • Molecular Formula: C₂₅H₂₃ClN₂O₅
  • Molecular Weight: 466.91
  • Purity: ≥95%
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Duocarmycin TM (Cat.No:I019771) is a potent antitumor antibiotic with cytotoxic properties. It belongs to the duocarmycin family and exhibits DNA alkylating activity, leading to cell cycle arrest and apoptosis in cancer cells. Duocarmycin TM shows promise as a potential therapeutic agent in the treatment of various cancers. 

Catalog Number I019771
CAS Number 157922-77-5
Molecular Formula

C₂₅H₂₃ClN₂O₅

Purity 95%
IUPAC Name [(1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydrobenzo[e]indol-3-yl]-(5,6,7-trimethoxy-1H-indol-2-yl)methanone
InChI InChI=1S/C25H23ClN2O5/c1-31-20-9-13-8-17(27-22(13)24(33-3)23(20)32-2)25(30)28-12-14(11-26)21-16-7-5-4-6-15(16)19(29)10-18(21)28/h4-10,14,27,29H,11-12H2,1-3H3/t14-/m1/s1
InChIKey NRHDGIYFJJUFKN-CQSZACIVSA-N
SMILES COC1=C(C(=C2C(=C1)C=C(N2)C(=O)N3C[C@H](C4=C3C=C(C5=CC=CC=C54)O)CCl)OC)OC
Reference

[1]. Dale L. Boger, et al. Critical Role of the Linking Amide in CC-1065 and the Duocarmycins: Implications on the Source of DNA Alkylation Catalysis. J. Am. Chem. Soc. 1998, 120, 11554-11557.

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