DTBHQ

• CAT Number: T000036
• CAS Number: 88-58-4
• Molecular Formula: C14H22O2
• Molecular Weight: 222.328
• Purity: ≥95%
• Target: ATPase
• Solubility: In methanol and organic solvents
• Storage: Store at RT
• IUPAC Name: 2,5-ditert-butylbenzene-1,4-diol
• InChI: InChI=1S/C14H22O2/c1-13(2,3)9-7-12(16)10(8-11(9)15)14(4,5)6/h7-8,15-16H,1-6H3
• InChIKey: JZODKRWQWUWGCD-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=CC(=C(C=C1O)C(C)(C)C)O

It is a potent inhibitor of Ca2+/Mg2+ – ATPase.

Benzohydroquinone,synthetic
Ca2+ mobilizer: the effect of DTBHQ is to inhibit Ca2+ sequestration by the stores and not to stimulate a Ca2+ efflux pathway, suggesting that its inhibitory effects on microsomal Ca2+-ATPase probably underlies its effects on intracellular Ca2+ stores. In permeabilized rat hepatocytes, a maximal concentration (25 μ

Reference

– Oldershaw et al., /2,5-Di-(tert-butyl)-1,4-benzohydroquinone mobilizes inositol 1,4,5-triphosphate-sensitive and -insensitive Ca2+ stores/ FEBS Lett., (1990). 274(1-2):214-216

– Schilling et al., Biochem. J., (1992). 284:521

– Moore et al., FEBS Lett. (1987). 224:331

– Wictome et al., FEBS Lett. (1992). 304:109

– Mason et al., J. Biol. Chem. (1991). 266:20856