DSHS00884

• CAT Number: I017652
• CAS Number: 675104-49-1
• Molecular Formula: C₁₂H₁₂N₄O₂S₂
• Molecular Weight: 308.38
• Purity: ≥95%
• IUPAC Name: 3-[(2-nitrophenyl)sulfanylmethyl]-4-prop-2-enyl-1H-1,2,4-triazole-5-thione
• InChI: InChI=1S/C12H12N4O2S2/c1-2-7-15-11(13-14-12(15)19)8-20-10-6-4-3-5-9(10)16(17)18/h2-6H,1,7-8H2,(H,14,19)
• InChIKey: VWFIHGWHMXSTAO-UHFFFAOYSA-N
• SMILES: C=CCN1C(=NNC1=S)CSC2=CC=CC=C2[N+](=O)[O-]

DSHS00884 (Cat No.:I017652) is a highly potent inhibitor of human papillomavirus E6 protein, with an IC50 of 10 μM. It effectively stabilizes p53 levels in HPV-positive cells by blocking E6-mediated degradation of p53, with an IC50 range of 2.5-25 μM. DSHS00884 has the potential as a therapeutic agent in HPV-associated cancers by restoring p53 tumor suppressor function and inducing apoptosis.

Reference

[1]. Malecka KA, et al. Identification and characterization of small molecule human papillomavirus E6 inhibitors. ACS Chem Biol. 2014 Jul 18;9(7):1603-12.