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Dronedarone

Dronedarone

  • CAT Number: I001599
  • CAS Number: 141626-36-0
  • Molecular Formula: C31H44N2O5S
  • Molecular Weight: 556.77
  • Purity: ≥95%
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Dronedarone (Cat.No:I001599) is an antiarrhythmic medication used to treat atrial fibrillation and atrial flutter. It works by blocking certain potassium channels in the heart, thus prolonging the cardiac action potential and preventing abnormal heart rhythms.

Catalog Number I001599
CAS Number 141626-36-0
Molecular Formula

C31H44N2O5S

Purity 95%
Target CYP3A/CYP450
Solubility 10 mM in DMSO
Storage Store at -20°C
IUPAC Name N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide
InChI InChI=1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3/h13-18,23,32H,5-12,19-22H2,1-4H3
InChIKey ZQTNQVWKHCQYLQ-UHFFFAOYSA-N
SMILES CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC
Reference

<p style=/line-height:25px/>
<br>[1]. Piccinni C, et al.Trends in antiarrhythmic drug use after marketing authorization of dronedarone: comparison between Emilia Romagna (Italy) and Sweden.Eur J Clin Pharmacol. 2012 Sep 1.
<br>[2]. Benaim G, et al.The emerging role of amiodarone and dronedarone in Chagas disease.Nat Rev Cardiol. 2012 Aug 7.
<br>[3]. Rosman J, et al. Possible Proarrhythmia with Dronedarone.J Cardiovasc Electrophysiol. 2012 Jul 19.
<br>[4]. Kao DP, et al. Proarrhythmic Potential of Dronedarone: Emerging Evidence from Spontaneous Adverse Event Reporting.Pharmacotherapy. 2012 Jun 28.
<br>[5]. Manakshe G, Rao BH.Dronedarone-current status in management of atrial fibrillation.Indian Heart J. 2012 Mar-Apr;64(2):182-6. Epub 2012 Apr 28.
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