DRAK2-IN-1

• CAT Number: I017964
• CAS Number: 871837-60-4
• Molecular Formula: C₂₁H₂₀N₄O₃
• Molecular Weight: 376.41
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: N-[2-hydroxy-3-(3-nitroso-1H-indol-2-yl)-1H-indol-5-yl]pentanamide
• InChI: InChI=1S/C21H20N4O3/c1-2-3-8-17(26)22-12-9-10-16-14(11-12)18(21(27)24-16)20-19(25-28)13-6-4-5-7-15(13)23-20/h4-7,9-11,23-24,27H,2-3,8H2,1H3,(H,22,26)
• InChIKey: ZFZLSKZDOULLMO-UHFFFAOYSA-N
• SMILES: CCCCC(=O)NC1=CC2=C(C=C1)NC(=C2C3=C(C4=CC=CC=C4N3)N=O)O

DRAK2-IN-1（Cat No.:I017964）, also known as compound 16, is a potent and selective inhibitor of DRAK2 (Death-associated protein kinase-related apoptosis-inducing kinase 2). It acts as an ATP-competitive inhibitor with an IC50 value of 3 nM and a Ki value of 0.26 nM. Additionally, DRAK2-IN-1 exhibits inhibitory effects on DRAK1, another member of the DRAK family, with an IC50 value of 51 nM. This compound’s selectivity and potency make it a valuable tool for studying the functions of DRAK2 and DRAK1 and their potential therapeutic applications.

Reference

[1]. Jung ME, et al.Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening.Bioorg Med Chem Lett. 2016 Jun 1;26(11):2719-23