DPN

• CAT Number: I001643
• CAS Number: 1428-67-7
• Molecular Formula: C15H13NO2
• Molecular Weight: 239.3
• Purity: ≥95%
• Synonyms: (R)-2,3-bis(4-hydroxyphenyl)propanenitrile
• Target: Estrogen/progestogen Receptor
• Solubility: 100 mM in DMSO
• Storage: Desiccate at -20C
• InChIKey: GHZHWDWADLAOIQ-UHFFFAOYSA-N

DPN (CAT: I001643), also known as 2,3-bis(4-hydroxyphenyl)propionitrile, is a selective agonist for estrogen receptor β (ERβ). It exhibits high affinity and selectivity for ERβ over estrogen receptor α (ERα). DPN acts as an estrogen mimic and binds to ERβ, activating downstream signaling pathways associated with estrogen receptor activation. This specific binding to ERβ leads to various physiological effects, including regulation of gene expression, modulation of cell growth, and anti-inflammatory properties. DPN has been used as a research tool to study the distinct functions of ERβ and its potential therapeutic applications, such as in the treatment of neurodegenerative diseases, cardiovascular disorders, and cancer.

Reference

[1]. Suwanna N, et al. Neuroprotective effects of diarylpropionitrile against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons. Neurosci Lett. 2014 Aug 22;578:44-9.

[2]. Khalaj AJ, et al. Estrogen receptor (ER) β expression in oligodendrocytes is required for attenuation of clinical disease by an ERβ ligand. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19125-30.

[3]. Huang SY, et al. Estrogen receptor β agonist diarylpropionitrile inhibits lipopolysaccharide-induced regulated on activation normal T cell expressed and secreted (RANTES) production in macrophages by repressing nuclear factor κB activation. Fertil Steril. 2013 Jul;100(1):234-40.