Doxycycline hydrochloride

• CAT Number: I000301
• CAS Number: 10592-13-9
• Molecular Formula: C22H24N2O8.HCl
• Molecular Weight: 480.9
• Purity: ≥95%
• Target: MMP
• Solubility: DMSO:50 mg/mL
• Storage: Store at -20C
• IUPAC Name: (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
• InChI: InChI=1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31);1H/t7-,10+,14+,15-,17-,22-;/m0./s1
• InChIKey: PTNZGHXUZDHMIQ-CVHRZJFOSA-N
• SMILES: CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl

Doxycycline hydrochloride (CAT: I000301) is a broad-spectrum antibiotic of the tetracycline class. It exhibits bacteriostatic activity by inhibiting protein synthesis in susceptible bacteria. Doxycycline hydrochloride is effective against a wide range of gram-positive and gram-negative bacteria, as well as certain protozoa. It is commonly used to treat various bacterial infections, including respiratory tract infections, skin infections, urinary tract infections, and sexually transmitted diseases. Additionally, doxycycline hydrochloride has anti-inflammatory properties and is sometimes prescribed for the treatment of acne and certain inflammatory conditions.

Reference

[1]. Hoerauf, A., et al., Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production. Med Microbiol Immunol, 2003. 192(4): p. 211-6.
[2]. Briest, W., et al., Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther, 2011. 337(3): p. 621-7.
[3]. Taylor, M.J., et al., Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial. Lancet, 2005. 365(9477): p. 2116-21.