Dorzolomide Hydrochloride

• CAT Number: A000569
• CAS Number: 130693-82-2
• Molecular Formula: C10H17ClN2O4S3
• Molecular Weight: 360.9
• Purity: ≥95%
• Storage: -20°C
• InChI: 1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1
• InChIKey: OSRUSFPMRGDLAG-QMGYSKNISA-N
• SMILES: CCNC1CC(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.Cl

Dorzolamide (trade name Trusopt) is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent and topically applied in the form of eye drops. This drug, developed by Merck, was the first drug in human therapy (market introduction 1995) which resulted from structure-based drug design. Dorzolamide hydrochloride is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension. The combination of dorzolamide with timolol is marketed under the trade name Cosopt.

Reference

1:Simultaneous determination of dorzolamide HCL and timolol maleate in eye drops by two different spectroscopic methods. Erk N.J Pharm Biomed Anal. 2002 Apr 15;28(2):391-7. PMID: 11929684
2:The hypotensive efficacy of dorzolamide HCL-timolol maleate 0.50% vs concomitant use of the two drugs. Durante A, Aurilia P, Guarnaccia G, Boles Carenini B.Acta Ophthalmol Scand Suppl. 2000;(232):46. No abstract available. PMID: 11235533