Domperidone

• CAT Number: A000199
• CAS Number: 57808-66-9
• Molecular Formula: C22H24ClN5O2
• Molecular Weight: 425.9
• Purity: ≥95%
• Target: Dopamine D2 receptor
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• InChI: 1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)
• InChIKey: FGXWKSZFVQUSTL-UHFFFAOYSA-N
• SMILES: C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O

Domperidone is used to relieve nausea and vomiting; to increase the transit of food through the stomach (that is, as a prokinetic agent via increasing gastrointestinal peristalsis); and to promote lactation (breast milk production) by release of prolactin. It is also used in scientific research to study the biological function of dopamine, an important neurotransmitter and hormone, in the body.

Reference

1: Karunanayake A, Devanarayana NM, de Silva A, Gunawardena S, Rajindrajith S.
Randomized Controlled Clinical Trial on Value of Domperidone in Functional
Abdominal Pain in Children. J Pediatr Gastroenterol Nutr. 2017 Nov 3. doi:
10.1097/MPG.0000000000001819. [Epub ahead of print] PubMed PMID: 29112086.

2: Heckert J, Parkman HP. Therapeutic response to domperidone in gastroparesis:
A prospective study using the GCSI-daily diary. Neurogastroenterol Motil. 2017
Nov 7. doi: 10.1111/nmo.13246. [Epub ahead of print] PubMed PMID: 29110425.

3: Bacchi S, Chim I, Kramer P, Postuma RB. Domperidone for Hypotension in
Parkinson/’s Disease: A Systematic Review. J Parkinsons Dis. 2017;7(4):603-617.
doi: 10.3233/JPD-171209. PubMed PMID: 29103053.

4: Doyle M, Grossman M. Case report: domperidone use as a galactagogue resulting
in withdrawal symptoms upon discontinuation. Arch Womens Ment Health. 2017 Oct
31. doi: 10.1007/s00737-017-0796-8. [Epub ahead of print] PubMed PMID: 29090362.

5: Grzeskowiak LE. Domperidone for Lactation: What Health Care Providers Really
Should Know. Obstet Gynecol. 2017 Oct;130(4):913. doi:
10.1097/AOG.0000000000002286. PubMed PMID: 28937559.

6: Okamura T, Yamamoto T, Kimura S, Miki A, Abe K, Kita H. Impact of lubiprostone
on gastric-emptying profile and the possible effect of concomitant domperidone in
healthy adults
. Int J Clin Pharmacol Ther. 2017 Nov;55(11):861-865. doi:
10.5414/CP203014. PubMed PMID: 28933338.

7: Berger F, Saaïd S, van Gelder T, Stricker B, Becker M, van den Bemt P. Media
attention regarding sudden cardiac death associated with domperidone use does not
affect in hospital ECG recording. Pharmacoepidemiol Drug Saf. 2017
Nov;26(11):1418-1424. doi: 10.1002/pds.4321. Epub 2017 Sep 19. PubMed PMID:
28924989.

8: Finnikin S, Finnikin L. Viewpoint: Domperidone and breastfeeding. Br J Gen
Pract. 2017 Sep;67(662):408. doi: 10.3399/bjgp17X692345. PubMed PMID: 28860289;
PubMed Central PMCID: PMC5569724.

9: Teeling M, MacAvin MJ, Bennett K. Impact of safety warnings on domperidone
prescribing in Ireland. Ir J Med Sci. 2017 Jul 20. doi:
10.1007/s11845-017-1657-1. [Epub ahead of print] PubMed PMID: 28730460.

10: Smolina K, Morgan S, Mintzes B, Hanley G, Oberlander T. Response to /use of
domperidone and risk of ventricular arrhythmia in the postpartum period: Getting
to the heart of the matter/. Pharmacoepidemiol Drug Saf. 2017 Jul;26(7):865-866.
doi: 10.1002/pds.4229. PubMed PMID: 28671317.