DMT-2’O-TBDMS-rA(bz) Phosphoramidite

• CAT Number: R029651
• CAS Number: 104992-55-4
• Molecular Formula: C53H66N7O8PSi
• Molecular Weight: 988.211
• Purity: ≥95%
• Synonyms: N-Benzoyl-5’-O-[bis(4-methoxyphenyl)phenylmethyl]-2’-O-[(1,1-dimethylethyl)dimethylsilyl]-adenosine 3’-[2-Cyanoethyl bis(1-methylethyl)phosphoramidite]
• Storage: Store at -20°C
• IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide
• InChI: InChI=1S/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/m1/s1
• InChIKey: FFXHNCNNHASXCT-RFMFGJHUSA-N
• SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C2N=CN=C3NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

DMT-2’O-TBDMS-rA(bz) Phosphoramidite (CAT: R029651) is a specialized compound crucial for nucleic acid synthesis. Employed in DNA modification, it facilitates targeted changes in DNA sequences during automated synthesis. Its components – DMT (dimethoxytrityl), TBDMS (tert-butyldimethylsilyl), and a benzoyl-modified riboadenosine – enable controlled modifications. Used extensively in biotechnology, this phosphoramidite empowers the creation of customized DNA strands, pivotal in genetic research, gene function analysis, and therapeutic nucleotide development. As a cornerstone of molecular biology, its precise utilization in DNA synthesis underscores its significance in advancing scientific understanding and applications.