DMH-1

• CAT Number: I000766
• CAS Number: 1206711-16-1
• Molecular Formula: C₂₄H₂₀N₄O
• Molecular Weight: 380.44
• Purity: ≥95%
• Target: TGF-βR1(ALK5)
• Solubility: DMSO: ≤ 11.5 mg/mL
• Storage: 2-8°C
• IC50: 27/107.9/<5 nM(ALK1/2/3)
• IUPAC Name: 4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
• InChI: InChI=1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3
• InChIKey: JMIFGARJSWXZSH-UHFFFAOYSA-N
• SMILES: CC(C)OC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=NC5=CC=CC=C45)N=C2

DMH1 (Cat No.: I000766) is a highly selective inhibitor of BMP (Bone Morphogenetic Protein) receptors. It effectively inhibits ALK2 with an IC50 of 107.9 nM while displaying no inhibitory effects on AMPK, ALK5, KDR (VEGFR-2), or PDGFR. Additionally, DMH1 is known to inhibit autophagy, making it a valuable tool in research related to BMP signaling and autophagy modulation. Should you require further information or have inquiries, please do not hesitate to contact us. Our team is committed to providing a prompt response within 24 hours.

Reference

[1]. Engers DW, et al. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.
[2]. Neely MD, et al. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS Chem Neurosci. 2012 Jun 20;3(6):482-91.