dmDNA31 (CAT: I018041) is a rifamycin-class antibiotic that acts by inhibiting bacterial DNA-dependent RNA polymerase. It displays potent bactericidal activity specifically against Staphylococcus aureus, a common pathogenic bacterium. By targeting the DNA-dependent RNA polymerase, dmDNA31 disrupts the essential process of RNA synthesis in bacteria, leading to the inhibition of bacterial growth and ultimately causing cell death. This antibiotic is of particular interest due to its efficacy against S. aureus, which is known for its resistance to many conventional antibiotics.
| Catalog Number | I018041 |
| CAS Number | 845625-44-7 |
| Molecular Formula | C₅₀H₆₂N₄O₁₃ |
| Purity | 95% |
| Reference | [1]. Peck M, et al. A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti-Staphylococcus aureus Thiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers. Antimicrob Agents Chemother. 2019 May 24;63(6). |
