DMAT

• CAT Number: I004781
• CAS Number: 749234-11-5
• Molecular Formula: C9H7Br4N3
• Molecular Weight: 476.8
• Purity: ≥95%
• Target: CK2
• Solubility: DMSO 25 mg/ml
• Storage: Store at -20°C
• IC50: 0.13 uM. DMAT also displays submicromolar IC50 values with almost all of the other kinases with special reference to PKD1, PIM3 and PIM1[3].
• InChIKey: SLPJGDQJLTYWCI-UHFFFAOYSA-N

DMAT(CAT: I004781), also known as 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole, is a potent and selective inhibitor of protein kinases, particularly CK2 (casein kinase 2). It acts by competitively binding to the ATP-binding pocket of CK2, preventing its activity and downstream signaling. DMAT has been widely used as a research tool to study the role of CK2 in various cellular processes, including cell growth, proliferation, and apoptosis. Furthermore, DMAT has shown potential therapeutic applications in cancer treatment due to its ability to inhibit CK2, which is often dysregulated in cancer cells and contributes to their survival and proliferation.

Reference

1:Experience from the Great East Japan Earthquake response as the basis for revising the Japanese Disaster Medical Assistance Team (DMAT) training program. Anan H, Akasaka O, Kondo H, Nakayama S, Morino K, Homma M, Koido Y, Otomo Y.Disaster Med Public Health Prep. 2014 Dec;8(6):477-84. doi: 10.1017/dmp.2014.113. Epub 2014 Nov 20. PMID: 25410400 2:Quinone reductase 2 is an adventitious target of protein kinase CK2 inhibitors TBBz (TBI) and DMAT. Leung KK, Shilton BH.Biochemistry. 2015 Jan 13;54(1):47-59. doi: 10.1021/bi500959t. Epub 2014 Nov 18. PMID: 25379648 3:Tenfibgen-DMAT Nanocapsule Delivers CK2 Inhibitor DMAT to Prostate Cancer Xenograft Tumors Causing Inhibition of Cell Proliferation. Trembley JH, Unger GM, Gomez OC, Abedin J, Korman VL, Vogel RI, Niehans G, Kren BT, Ahmed K.Mol Cell Pharmacol. 2014;6(2):15-25. PMID: 25893034 Free PMC Article4:[Experience of DMAT rescue activity by doctor-helicopter in Tohoku Area after the earthquake]. Otsuka N, Yamashita A, Kimura Y, Aimono M, Kobayashi I, Nanba H, Watanabe A, Sumita S.Masui. 2012 Jul;61(7):771-4. Japanese. PMID: 22860313 5:[Series: Physicians and disaster medical care; the 108th annual scientific meeting of the Japanese Society of Internal Medicine, Special Symposium on /Physicians and disaster medical care/; relation of DMAT activity and the medical disease in the East Japan great earthquake disaster]. Anan H.Nihon Naika Gakkai Zasshi. 2012 Apr 10;101(4):1132-5. Japanese. No abstract available. PMID: 22730749 6:Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT. Sass G, Klinger N, Sirma H, Hashemolhosseini S, Hellerbrand C, Neureiter D, Wege H, Ocker M, Tiegs G.Int J Oncol. 2011 Aug;39(2):433-42. doi: 10.3892/ijo.2011.1037. Epub 2011 May 10. PMID: 21567083 7:An analysis of Japan Disaster Medical Assistance Team (J-DMAT) deployments in comparison with those of J-DMAT/’s counterpart in the United States (US-DMAT). Fuse A, Yokota H.J Nippon Med Sch. 2010 Dec;77(6):318-24. PMID: 21206145 Free Article8:First Responders: The DMAT Team. O/’Young J.Perm J. 2010 Fall;14(3):86-7. No abstract available. PMID: 20844717 Free PMC Article9:Concerns of Disaster Medical Assistance Team (DMAT) members about troubles at the nuclear power plant: experience from the Niigata Chuetsu-Oki earthquake, 16 July 2007, in Japan. Akashi M, Kumagaya K, Kondo H, Hirose Y.Health Phys. 2010 Jun;98(6):804-9. doi: 10.1097/HP.0b013e3181ac924a. PMID: 20445385 10:Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Lawnicka H, Kowalewicz-Kulbat M, Sicinska P, Kazimierczuk Z, Grieb P, Stepien H.Cell Tissue Res. 2010 May;340(2):371-9. doi: 10.1007/s00441-010-0960-1. Epub 2010 Apr 6. PMID: 20383646