Disulfiram

• CAT Number: A000724
• CAS Number: 97-77-8
• Molecular Formula: C₁₀H₂₀N₂S₄
• Molecular Weight: 296.54
• Purity: ≥95%
• Target: Dopamine β-hydroxylase
• Solubility: >12mg/mL in DMSO
• Storage: -20°C
• InChI: InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
• InChIKey: AUZONCFQVSMFAP-UHFFFAOYSA-N
• SMILES: CCN(CC)C(=S)SSC(=S)N(CC)CC

Disulfiram is used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (alcohol). Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase.

Reference

1: Wang NN, Wang LH, Li Y, Fu SY, Xue X, Jia LN, Yuan XZ, Wang YT, Tang X, Yang
JY, Wu CF. Targeting ALDH2 with disulfiram/copper reverses the resistance of
cancer cells to microtubule inhibitors. Exp Cell Res. 2017 Nov 16. pii:
S0014-4827(17)30600-6. doi: 10.1016/j.yexcr.2017.11.004. [Epub ahead of print]
PubMed PMID: 29155365.

2: Li Y, Wang LH, Zhang HT, Wang YT, Liu S, Zhou WL, Yuan XZ, Li TY, Wu CF, Yang
JY. Disulfiram combined with copper inhibits metastasis and
epithelial-mesenchymal transition in hepatocellular carcinoma through the NF-κB
and TGF-β pathways. J Cell Mol Med. 2017 Nov 17. doi: 10.1111/jcmm.13334. [Epub
ahead of print] PubMed PMID: 29148232.

3: Karamanakos PN, Trafalis DT, Papachristou DJ, Panteli ES, Papavasilopoulou M,
Karatzas A, Kardamakis D, Nasioulas G, Marselos M. Evidence for the efficacy of
disulfiram and copper combination in glioblastoma multiforme – A propos of a
case. J BUON. 2017 Sep-Oct;22(5):1227-1232. PubMed PMID: 29135106.

4: Di Ciano P, Manvich DF, Pushparaj A, Gappasov A, Hess EJ, Weinshenker D, Le
Foll B. Effects of disulfiram on choice behavior in a rodent gambling task:
association with catecholamine levels. Psychopharmacology (Berl). 2017 Oct 30.
doi: 10.1007/s00213-017-4744-0. [Epub ahead of print] PubMed PMID: 29085979.

5: Stokes M, Abdijadid S. Disulfiram. 2017 Oct 14. StatPearls [Internet].
Treasure Island (FL): StatPearls Publishing; 2017 Jun-. Available from
http://www.ncbi.nlm.nih.gov/books/NBK459340/
PubMed PMID: 29083801.

6: Viola-Rhenals M, Patel KR, Jaimes-Santamaria L, Wu G, Liu J, Dou QP. Recent
Advances in Antabuse (Disulfiram): the importance of its metal-binding ability to
its anticancer activity. Curr Med Chem. 2017 Oct 23. doi:
10.2174/0929867324666171023161121. [Epub ahead of print] PubMed PMID: 29065820.

7: Tesson M, Anselmi G, Bell C, Mairs R. Cell cycle specific radiosensitisation
by the disulfiram and copper complex. Oncotarget. 2017 Jul 25;8(39):65900-65916.
doi: 10.18632/oncotarget.19539. eCollection 2017 Sep 12. PubMed PMID: 29029481;
PubMed Central PMCID: PMC5630381.

8: Liu C, Lan Q, He W, Nie C, Zhang C, Xu T, Jiang T, Wang S. Octa-arginine
modified lipid emulsions as a potential ocular delivery system for disulfiram: A
study of the corneal permeation, transcorneal mechanism and anti-cataract effect.
Colloids Surf B Biointerfaces. 2017 Aug 25;160:305-314. doi:
10.1016/j.colsurfb.2017.08.037. [Epub ahead of print] PubMed PMID: 28950195.

9: Hasinoff BB, Patel D. Disulfiram is a slow-binding partial noncompetitive
inhibitor of 20S proteasome activity. Arch Biochem Biophys. 2017 Nov 1;633:23-28.
doi: 10.1016/j.abb.2017.09.003. Epub 2017 Sep 5. PubMed PMID: 28887129.

10: Fasehee H, Ghavamzadeh A, Alimoghaddam K, Ghaffari SH, Faghihi S. A
Comparative Cytotoxic Evaluation of Disulfiram Encapsulated PLGA Nanoparticles on
MCF-7 Cells. Int J Hematol Oncol Stem Cell Res. 2017 Apr 1;11(2):102-107. PubMed
PMID: 28875004; PubMed Central PMCID: PMC5575722.