Diphenyleneiodonium chloride

• CAT Number: R000095
• CAS Number: 4673-26-1
• Molecular Formula: C12H8ClI
• Molecular Weight: 314.55
• Purity: ≥95%
• Synonyms: DPI Chloride; Dibenz[b,d]iodolium Chloride
• Target: Nitric Oxide
• Solubility: Soluble in DMSO > 10 mM
• Storage: Desiccate at -20C
• IUPAC Name: 8-iodoniatricyclo[7.4.0.02,7]trideca-1(13),2,4,6,9,11-hexaene;chloride
• InChI: InChI=1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1
• InChIKey: FCFZKAVCDNTYID-UHFFFAOYSA-M
• SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3[I+]2.[Cl-]

Diphenyleneiodonium chloride (Cat No.:R000095) is a chemical compound commonly used as an inhibitor of flavoenzymes, particularly NADPH oxidases (NOX enzymes). It works by inhibiting the flavin-containing active site of these enzymes, thereby blocking the transfer of electrons across biological membranes. DPI is widely used in research to study the role of NOX enzymes in various physiological and pathological processes, including inflammation, cardiovascular diseases, and cancer. Additionally, DPI is used as a tool in cell biology to investigate the involvement of NOX enzymes in cellular signaling pathways and oxidative stress.