Diphenidol

• CAT Number: I006390
• CAS Number: 972-02-1
• Molecular Formula: C21H27NO
• Molecular Weight: 309.45
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol
• InChI: InChI=1S/C21H27NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-2,4-7,11-14,23H,3,8-10,15-18H2
• InChIKey: OGAKLTJNUQRZJU-UHFFFAOYSA-N
• SMILES: C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O

Diphenidol (Cat.No:I006390) is an anticholinergic and antihistamine medication primarily used to treat nausea and vomiting, particularly associated with motion sickness. It works by blocking certain receptors in the brain and inner ear, reducing the symptoms of motion-related discomfort. 

Reference

1:Fatal diphenidol poisoning: a case report and a retrospective study of 16 cases. Zhang L, Ma J, Li S, Xue R, Jin M, Zhou Y.Forensic Sci Med Pathol. 2015 Dec;11(4):570-6. doi: 10.1007/s12024-015-9709-1. Epub 2015 Oct 19. PMID: 26481789 2:High frequency transcutaneous electrical nerve stimulation with diphenidol administration results in an additive antiallodynic effect in rats following chronic constriction injury. Lin HT, Chiu CC, Wang JJ, Hung CH, Chen YW.Neurosci Lett. 2015 Mar 4;589:62-6. doi: 10.1016/j.neulet.2015.01.026. Epub 2015 Jan 14. PMID: 25596445 3:Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury. Chen YW, Tzeng JI, Liu KS, Yu SH, Hung CH, Wang JJ.Neurosci Lett. 2013 Sep 27;552:62-5. doi: 10.1016/j.neulet.2013.07.030. Epub 2013 Jul 31. PMID: 23916656 4:Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Leung YM, Wong KL, Cheng KS, Kuo CS, Su TH, Chen YW, Cheng TH.Pharmacol Rep. 2012;64(3):739-44. PMID: 22814027 Free Article5:Diphenidol inhibited sodium currents and produced spinal anesthesia. Leung YM, Wu BT, Chen YC, Hung CH, Chen YW.Neuropharmacology. 2010 Jun;58(7):1147-52. doi: 10.1016/j.neuropharm.2010.02.007. Epub 2010 Feb 20. PMID: 20176039 6:Ultra-fast chromatographic micro-assay for quantification of diphenidol in plasma: application in an oral multi-dose switchability trial. Marcelín-Jiménez G, Morales-Martínez M, Angeles-Moreno AP, Mendoza-Morales L.Biomed Chromatogr. 2008 Oct;22(10):1143-8. doi: 10.1002/bmc.1037. PMID: 18506741 7:Diphenidol-related diamines as novel muscarinic M4 receptor antagonists. Varoli L, Andreani A, Burnelli S, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Bedini A, Fazio N, Spampinato S.Bioorg Med Chem Lett. 2008 May 1;18(9):2972-6. doi: 10.1016/j.bmcl.2008.03.061. Epub 2008 Mar 23. PMID: 18395442 8:Synthesis and pharmacological profile of a series of 1-substituted-2-carbonyl derivatives of Diphenidol: novel M4 muscarinic receptor antagonists. Varoli L, Angeli P, Buccioni M, Burnelli S, Fazio N, Marucci G, Recanatini M, Spampinato S.Med Chem. 2008 Mar;4(2):121-8. PMID: 18336331 9:Development of an HPLC method for determination of diphenidol in plasma and its application in an oral multi-dose bioequivalence study in a healthy female Mexican population. Hernández J, Marcelín-Jiménez G, Rivera L, Alionka PA, Contreras L, Hinojosa M, Martínez-Rossier L, Amancio O, Fernández A.J Pharm Biomed Anal. 2005 Jul 15;38(4):746-50. Epub 2005 Apr 13. PMID: 15967303 10:Diphenidol has no actual broad antiemetic activity in dogs and ferrets. Nakayama H, Yamakuni H, Nakayama A, Maeda Y, Imazumi K, Matsuo M, Mutoh S.J Pharmacol Sci. 2004 Nov;96(3):301-6. Epub 2004 Nov 5. PMID: 15528840 Free Article