DIPHENHYDRAMINE

• CAT Number: T000031
• CAS Number: 58-73-1
• Molecular Formula: C17H21NO
• Molecular Weight: 255.361
• Purity: ≥95%
• Solubility: In water
• Storage: Store in dark, cool place Reconstitution: soluble in weak acidic solvent soluble in weak acidic solvent
• IUPAC Name: 2-benzhydryloxy-N,N-dimethylethanamine
• InChI: InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3
• InChIKey: ZZVUWRFHKOJYTH-UHFFFAOYSA-N
• SMILES: CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2

DIPHENHYDRAMINE(cas 58-73-1) is an antihistaminic H1<!–[if gte mso 9]><![endif]–>


It has antihistaminic H1 activity and so antimuscarinic activity too.
It has also anticholinergic proably due to its antimuscrinic action.

Reference

1:Diphenhydramine inhibits voltage-gated proton channels (Hv1) and induces acidification in leukemic Jurkat T cells- New insights into the pro-apoptotic effects of antihistaminic drugs. Asuaje A, Martín P, Enrique N, Díaz Zegarra LA, Smaldini P, Docena G, Milesi V.Channels (Austin). 2017 May 17:0. doi: 10.1080/19336950.2017.1331799. [Epub ahead of print] PMID: 28514187 2:Over-the-counter medications containing diphenhydramine and doxylamine used by older adults to improve sleep. Abraham O, Schleiden L, Albert SM.Int J Clin Pharm. 2017 May 2. doi: 10.1007/s11096-017-0467-x. [Epub ahead of print] PMID: 28466395 3:Continuous diphenhydramine infusion and imatinib for KIT-D816V-negative mast cell activation syndrome: a case report. Malik F, Ali N, Jafri SIM, Ghani A, Hamid M, Boigon M, Fidler C.J Med Case Rep. 2017 Apr 24;11(1):119. doi: 10.1186/s13256-017-1278-3. PMID: 28438191 Free PMC Article4:Randomized Trial of Adding Parenteral Acetaminophen to Prochlorperazine and Diphenhydramine to Treat Headache in the Emergency Department. Meyering SH, Stringer RW, Hysell MK.West J Emerg Med. 2017 Apr;18(3):373-381. doi: 10.5811/westjem.2016.12.29218. Epub 2017 Feb 27. PMID: 28435487 Free PMC Article5:Ontogenetic dietary shifts and bioaccumulation of diphenhydramine in Mugil cephalus from an urban estuary. Haddad SP, Du B, Scott WC, Saari GN, Breed C, Kelly M, Broach L, Chambliss CK, Brooks BW.Mar Environ Res. 2017 Jun;127:155-162. doi: 10.1016/j.marenvres.2017.03.006. Epub 2017 Mar 23. PMID: 28365158 6:Elimination half-life of diphenhydramine in overdose. Varma A, Ford L, Patel N, Vale JA.Clin Toxicol (Phila). 2017 Jul;55(6):615-616. doi: 10.1080/15563650.2017.1296153. Epub 2017 Mar 28. No abstract available. PMID: 28349707 7:Diphenhydramine as a Cause of Drug-Induced Liver Injury. Namn Y, Schneider Y, Cui IH, Jesudian A.Case Reports Hepatol. 2017;2017:3864236. doi: 10.1155/2017/3864236. Epub 2017 Jan 26. PMID: 28246565 Free PMC Article8:Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial. Sachar H, Pichetshote N, Nandigam K, Vaidya K, Laine L.Gastrointest Endosc. 2017 Jan 31. pii: S0016-5107(17)30072-X. doi: 10.1016/j.gie.2017.01.028. [Epub ahead of print] PMID: 28159539 9:Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells. Kim J, Song JH.Eur J Pharmacol. 2017 Mar 5;798:122-128. doi: 10.1016/j.ejphar.2017.01.032. Epub 2017 Jan 26. PMID: 28131782 10:[Effectiveness of intravenous sedation with midazolam-diphenhydramine in patients who are going to perform an magnetic resonance]. Álvarez-Bastidas L, Sabag-Ruiz E, Medina-Soto A.Gac Med Mex. 2017 Jan-Feb;153(1):57-60. Spanish. PMID: 28128807 Free Article