Diosmin

• CAT Number: R010404
• CAS Number: 520-27-4
• Molecular Formula: C28H32O15
• Molecular Weight: 608.5
• Purity: ≥95%
• Storage: 2-8°C
• IUPAC Name: 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
• InChI: InChI=1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1
• InChIKey: GZSOSUNBTXMUFQ-YFAPSIMESA-N
• SMILES: CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

Diosmin (Cat No.:R010404) is a naturally occurring flavonoid glycoside found in various plants, particularly citrus fruits. It is known for its potential medicinal properties, primarily in improving vascular health. Diosmin is commonly used as a dietary supplement and medication for managing conditions related to blood vessels and circulation, such as chronic venous insufficiency, hemorrhoids, and leg ulcers. It works by strengthening blood vessel walls, reducing inflammation, and enhancing blood flow. Diosmin is often combined with hesperidin, another flavonoid, to enhance its effectiveness. It plays a valuable role in promoting vascular health and managing related medical conditions.

Reference

1:[The effects of diosmin and hesperidin on capillary blood flow of upper limbs in patients with secondary Raynaud/’s syndrome]. Zudin AM, Gritsenko AG, Hadzhishvili IT.Khirurgiia (Mosk). 2017;(5):60-66. doi: 10.17116/hirurgia2017560-66. Russian. PMID: 28514385 2:Diosmin/essential oil combination for dermal photo-protection using a lipoid colloidal carrier. Kamel R, Abbas H, Fayez A.J Photochem Photobiol B. 2017 Mar 30;170:49-57. doi: 10.1016/j.jphotobiol.2017.03.019. [Epub ahead of print] PMID: 28390258 3:Use of multiresponse statistical techniques to optimize the separation of diosmin, hesperidin, diosmetin and hesperitin in different pharmaceutical preparations by high performance liquid chromatography with UV-DAD. Sammani MS, Clavijo S, Portugal L, Suárez R, Seddik H, Cerdà V.Talanta. 2017 May 15;167:695-702. doi: 10.1016/j.talanta.2017.02.069. Epub 2017 Mar 2. PMID: 28340781 4:Antihyperglycaemic action of diosmin, a citrus flavonoid, is induced through endogenous β-endorphin in type I-like diabetic rats. Hsu CC, Lin MH, Cheng JT, Wu MC.Clin Exp Pharmacol Physiol. 2017 May;44(5):549-555. doi: 10.1111/1440-1681.12739. PMID: 28218955 5:Diosmin attenuates radiation-induced hepatic fibrosis by boosting PPAR-γ expression and hampering miR-17-5p-activated canonical Wnt-β-catenin signaling. Hasan HF, Abdel-Rafei MK, Galal SM.Biochem Cell Biol. 2016 Nov 21:1-15. doi: 10.1139/bcb-2016-0142. [Epub ahead of print] PMID: 28177765 6:Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity. Lewinska A, Adamczyk-Grochala J, Kwasniewicz E, Deregowska A, Wnuk M.Toxicol Lett. 2017 Jan 4;265:117-130. doi: 10.1016/j.toxlet.2016.11.018. Epub 2016 Nov 24. PMID: 27890807 7:Effect of a mixture of diosmin, coumarin glycosides, and triterpenes on bleeding, thrombosis, and pain after stapled anopexy: a prospective, randomized, placebo-controlled clinical trial. Schiano di Visconte M, Nicolì F, Del Giudice R, Cipolat Mis T.Int J Colorectal Dis. 2017 Mar;32(3):425-431. doi: 10.1007/s00384-016-2698-z. Epub 2016 Nov 4. PMID: 27815700 8:Influence of diosmin on the metabolism and disposition of carbamazepine in healthy subjects. Bedada SK, Boga PK.Xenobiotica. 2016 Oct 28:1-6. doi: 10.1080/00498254.2016.1244368. [Epub ahead of print] PMID: 27690733 9:Diosmin induce apoptosis through modulation of STAT-3 signaling in 7,12 dimethylbenz(a)anthracene induced harmster buccal pouch carcinogenesis. Rajasekar M, Suresh K, Sivakumar K.Biomed Pharmacother. 2016 Oct;83:1064-1070. doi: 10.1016/j.biopha.2016.08.019. Epub 2016 Aug 19. PMID: 27544550 10:[Safety of use of micronized diosmin at daily doses up to 2000 mg per day]. Staniewska A.Pol Merkur Lekarski. 2016 Oct 19;41(244):188-191. Polish. PMID: 27760093