Dimethyl Fumarate

• CAT Number: A000346
• CAS Number: 624-49-7
• Molecular Formula: C₆H₈O₄
• Molecular Weight: 144.13
• Purity: ≥95%
• Target: KEAP1-Nrf2
• Solubility: >7.1mg/mL in DMSO
• Storage: 3 years -20C powder
• InChI: InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+
• InChIKey: LDCRTTXIJACKKU-ONEGZZNKSA-N
• SMILES: COC(=O)/C=C/C(=O)OC

Dimethyl fumarate (DMF)is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis.Dimethyl fumarate causes short-lived oxidative stress, which leads to increased levels and nuclear localization of the transcription factor nuclear factor erythroid 2-related factor 2 and a subsequent increase in glutathione synthesis and recycling in neuronal cells.Dimethyl fumarate inhibits nuclear entry of NF-kappaB in RHEC and reduces myocardial infarct size after ischemia and reperfusion in rats in vivo.