Dimenhydrinate

• CAT Number: I003916
• CAS Number: 523-87-5
• Molecular Formula: C24H28ClN5O3
• Molecular Weight: 469.96
• Purity: ≥95%
• Solubility: DMSO:37mg/mL
• Storage: Room Temperature
• IUPAC Name: 2-benzhydryloxy-N,N-dimethylethanamine;8-chloro-1,3-dimethyl-7H-purine-2,6-dione
• InChI: InChI=1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10)
• InChIKey: NFLLKCVHYJRNRH-UHFFFAOYSA-N
• SMILES: CN1C2=C(C(=O)N(C1=O)C)NC(=N2)Cl.CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2

Dimenhydrinate（Cat No.:I003916） is a medication with anti-emetic (anti-nausea) and anti-histamine properties. It is often found over-the-counter as a remedy for motion sickness. Dimenhydrinate works by blocking histamine receptors in the brain, reducing nausea and preventing vomiting associated with motion sickness. It is commonly used to alleviate symptoms of travel-related nausea, vertigo, and dizziness.

Reference

1:Comparison of Dexamethasone-Dimenhydrinate and Dexamethasone-Ondansetron in Prevention of Nausea and Vomiting in Postoperative Patients. Kizilcik N, Bilgen S, Menda F, Türe H, Aydın B, Kaspar EC, Koner O.Aesthetic Plast Surg. 2017 Feb;41(1):204-210. doi: 10.1007/s00266-016-0772-0. Epub 2016 Dec 30. PMID: 28039501 2:Full spectrum and selected spectrum based chemometric methods for the simultaneous determination of Cinnarizine and Dimenhydrinate in laboratory prepared mixtures and pharmaceutical dosage form. Tawakkol SM, El-Zeiny MB, Hemdan A.Spectrochim Acta A Mol Biomol Spectrosc. 2017 Feb 15;173:892-896. doi: 10.1016/j.saa.2016.10.055. Epub 2016 Nov 1. PMID: 27837737 3:Preoperative Use of 10-mg Metoclopramide and 50-mg Dimenhydrinate in the Prophylaxis of Postoperative Nausea and Vomiting in Elective Caesarean Births: A Prospective Randomized Clinical Study. Hüseyinoğlu Ü, Ülker K.J Obstet Gynaecol India. 2016 Aug;66(4):252-8. doi: 10.1007/s13224-015-0679-8. Epub 2015 May 9. PMID: 27382219 4:Abuse and Misuse Potential of Dimenhydrinate: A Review of the Clinical Evidence [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Dec 1. PMID: 26985532 Free Books & Documents5:Selective determination of dimenhydrinate in presence of six of its related substances and potential impurities using a direct GC/MS method. Belal TS, Abdel-Hay KM, Clark CR.J Adv Res. 2016 Jan;7(1):53-8. doi: 10.1016/j.jare.2015.01.010. Epub 2015 Feb 7. PMID: 26843970 Free PMC Article6:Effect of Oral Dimenhydrinate in Children with Acute Gastroenteritis: A Clinical Trial. Gheini S, Ameli S, Hoseini J.Oman Med J. 2016 Jan;31(1):18-21. doi: 10.5001/omj.2016.04. PMID: 26813018 Free PMC Article7:Successful Treatment of Paroxysmal Movement Disorders of Infancy With Dimenhydrinate and Diphenhydramine. Sawicka KM, Goez H, Huntsman RJ.Pediatr Neurol. 2016 Mar;56:72-5. doi: 10.1016/j.pediatrneurol.2015.10.019. Epub 2015 Nov 26. PMID: 26726052 8:Diphenhydramine, dimenhydrinate: misuse. [No authors listed]Prescrire Int. 2015 Nov;24(165):270. No abstract available. PMID: 26688907 9:Cinnarizine and dimenhydrinate in the treatment of vertigo in medical practice. Scholtz AW, Ilgner J, Loader B, Pritschow BW, Weisshaar G.Wien Klin Wochenschr. 2016 May;128(9-10):341-7. doi: 10.1007/s00508-015-0905-5. Epub 2015 Dec 11. PMID: 26659910 Free PMC Article10:Preparation and in-vivo evaluation of dimenhydrinate buccal mucoadhesive films with enhanced bioavailability. Yildiz Pekoz A, Sedef Erdal M, Okyar A, Ocak M, Tekeli F, Kaptan E, Sagirli O, Araman A.Drug Dev Ind Pharm. 2016;42(6):916-25. doi: 10.3109/03639045.2015.1091470. Epub 2015 Oct 12. PMID: 26460061