Diltiazem

• CAT Number: I006490
• CAS Number: 42399-41-7
• Molecular Formula: C22H26N2O4S
• Molecular Weight: 414.52
• Purity: ≥95%
• Synonyms: CRD 401; CRD-401; CRD401; Diltiazem; Dilticard; Dilzen;4-oxo-4,5-dihydrobenzo[b][1,4]thiazepin-3-yl acetate
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
• InChI: InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
• InChIKey: HSUGRBWQSSZJOP-RTWAWAEBSA-N
• SMILES: CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC

Diltiazem (Cat.No:I006490) is a nondihydropyridines (non-DHP) calcium channel blocker used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. It relaxes the smooth muscles in the walls of arteries, which opens (dilates) the arteries, allows blood to flow more easily, and lowers blood pressure.

Reference

1:A Critical Note on Treatment of a Severe Diltiazem Intoxication; High-Dose Calcium and Glucagon Infusions. Van Veggel NM, Van der Veen GJ, Jansen TC, Westerman EM.Basic Clin Pharmacol Toxicol. 2017 May 15. doi: 10.1111/bcpt.12809. [Epub ahead of print] PMID: 28503840 2:Systemic allergic dermatitis caused by diltiazem. Opstrup MS, Guldager S, Zachariae C, Thyssen JP.Contact Dermatitis. 2017 Jun;76(6):364-365. doi: 10.1111/cod.12719. No abstract available. PMID: 28497625 3:Atorvastatin-Diltiazem Combination Induced Rhabdomyolysis Leading to Diagnosis of Hypothyroidism. Ehelepola NDB, Sathkumara SMBY, Bandara HMPAGS, Kalupahana KLR.Case Rep Med. 2017;2017:8383251. doi: 10.1155/2017/8383251. Epub 2017 Apr 11. PMID: 28487744 Free PMC Article4:Effects of Cilostazol and Diltiazem Hydrochloride on Ischemia-Reperfusion Injury in a Rat Hindlimb Model. Inan B, Sönmez Ergün S, Nurten A, Küçükgergin C, Zengin Türkmen A, Seçkin Ş, Erkalp K, Ziyade S.Heart Surg Forum. 2017 Apr 29;20(2):E058-E065. doi: 10.1532/hsf.1663. PMID: 28481745 5:Effect of Diltiazem on Exercise Capacity after Heart Transplantation. Varnado S, Peled-Potashnik Y, Huntsberry A, Lowes BD, Zolty R, Burdorf A, Lyden ER, Moulton MJ, Um JY, Raichlin E.Clin Transplant. 2017 May 6. doi: 10.1111/ctr.12997. [Epub ahead of print] PMID: 28477381 6:Protective effects of diltiazem and tadalafil on shock wave-induced kidney injury in rats. Ozmerdiven G, Vuruskan BA, Kaygisiz O, Vuruskan H.Bratisl Lek Listy. 2017;118(4):228-232. doi: 10.4149/BLL_2017_045. PMID: 28471234 7:Diltiazem versus esmolol for acute rate control in the emergency department. Harvey S, Wilson K, Brad Hall A.Am J Emerg Med. 2017 Apr 4. pii: S0735-6757(17)30268-1. doi: 10.1016/j.ajem.2017.04.005. [Epub ahead of print] No abstract available. PMID: 28465013 8:In vitro and in vivo investigation for optimization of niosomal ability for sustainment and bioavailability enhancement of diltiazem after nasal administration. Ammar HO, Haider M, Ibrahim M, El Hoffy NM.Drug Deliv. 2017 Nov;24(1):414-421. doi: 10.1080/10717544.2016.1259371. PMID: 28165822 9:Terlipressin in refractory shock induced by diltiazem poisoning. Ragot C, Gerbaud E, Boyer A.Am J Emerg Med. 2017 Jan 27. pii: S0735-6757(17)30083-9. doi: 10.1016/j.ajem.2017.01.062. [Epub ahead of print] PMID: 28161219 10:Diltiazem prevents stress-induced contractile deficits in cardiomyocytes, but does not reverse the cardiomyopathy phenotype in Mybpc3-knock-in mice. Flenner F, Geertz B, Reischmann-Düsener S, Weinberger F, Eschenhagen T, Carrier L, Friedrich FW.J Physiol. 2017 Jan 15. doi: 10.1113/JP273769. [Epub ahead of print] PMID: 28090637