Dienogest

  • CAT Number: A001167
  • CAS Number: 65928-58-7
  • Molecular Formula: C20H25NO2
  • Molecular Weight: 311.4
  • Purity: ≥95%
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Dienogest is an orally active synthetic progesterone (or progestin). It is available for use as an oral contraceptive in combination with ethinylestradiol. It has antiandrogenic activity and as a result can improve androgenic symptoms. It is a non-ethinylated progestin which is structurally related to testosterone. Dienogest given in isolation is available for the treatment of endometriosis under the trade name Visanne. (Source: http://en.wikipedia.org/wiki/Dienogest).

Catalog Number A001167
CAS Number 65928-58-7
Synonyms

TS 557

Molecular Formula

C20H25NO2

Purity 95%
Target Estrogen/progestogen Receptor
Solubility >14.8mg/mL in DMSO
Storage 3 years -20C powder
InChIKey AZFLJNIPTRTECV-FUMNGEBKSA-N
Reference

</br>1:Dienogest inhibits C-C motif chemokine ligand 20 expression in human endometriotic epithelial cells. Mita S, Nakakuki M, Ichioka M, Shimizu Y, Hashiba M, Miyazaki H, Kyo S.Eur J Obstet Gynecol Reprod Biol. 2017 Apr 29;214:65-70. doi: 10.1016/j.ejogrb.2017.04.048. [Epub ahead of print] PMID: 28482330 </br>2:Effects of long-term postoperative dienogest use for treatment of endometriosis on bone mineral density. Seo JW, Lee DY, Yoon BK, Choi D.Eur J Obstet Gynecol Reprod Biol. 2017 May;212:9-12. doi: 10.1016/j.ejogrb.2017.03.011. Epub 2017 Mar 6. PMID: 28314166 </br>3:Dienogest and deep infiltrating endometriosis: The remission of symptoms is not related to endometriosis nodule remission. Leonardo-Pinto JP, Benetti-Pinto CL, Cursino K, Yela DA.Eur J Obstet Gynecol Reprod Biol. 2017 Apr;211:108-111. doi: 10.1016/j.ejogrb.2017.02.015. Epub 2017 Feb 15. PMID: 28231497 </br>4:Dienogest 2 mg Daily in the Treatment of Adolescents with Clinically Suspected Endometriosis: The VISanne Study to Assess Safety in ADOlescents. Ebert AD, Dong L, Merz M, Kirsch B, Francuski M, Böttcher B, Roman H, Suvitie P, Hlavackova O, Gude K, Seitz C.J Pediatr Adolesc Gynecol. 2017 Feb 9. pii: S1083-3188(17)30036-0. doi: 10.1016/j.jpag.2017.01.014. [Epub ahead of print] PMID: 28189702 Free Article</br>5:Long-term medical management of endometriosis with dienogest and with a gonadotropin-releasing hormone agonist and add-back hormone therapy. Bedaiwy MA, Allaire C, Alfaraj S.Fertil Steril. 2017 Mar;107(3):537-548. doi: 10.1016/j.fertnstert.2016.12.024. Epub 2017 Jan 27. Review. PMID: 28139239 </br>6:Efficacy and safety of dienogest in patients with endometriosis: A single-center observational study over 12 months. Park SY, Kim SH, Chae HD, Kim CH, Kang BM.Clin Exp Reprod Med. 2016 Dec;43(4):215-220. doi: 10.5653/cerm.2016.43.4.215. Epub 2016 Dec 26. PMID: 28090460 Free PMC Article</br>7:Immunohistochemical Analysis of the Effect of Dienogest on Ovarian Endometriotic Cysts. Nguyen TT, Hachisuga T, Urabe R, Ueda T, Kurita T, Kagami S, Kawagoe T, Hisaoka M.J UOEH. 2016;38(4):271-278. PMID: 27980309 Free Article</br>8:Endometrial preparation with Dienogest before hysteroscopic surgery: a systematic review. Laganà AS, Vitale SG, Muscia V, Rossetti P, Buscema M, Triolo O, Rapisarda AM, Giunta L, Palmara V, Granese R, Frangež HB, Romano A.Arch Gynecol Obstet. 2017 Mar;295(3):661-667. doi: 10.1007/s00404-016-4244-1. Epub 2016 Nov 30. PMID: 27904953 </br>9:Study of dienogest for dysmenorrhea and pelvic pain associated with endometriosis. Kim SA, Um MJ, Kim HK, Kim SJ, Moon SJ, Jung H.Obstet Gynecol Sci. 2016 Nov;59(6):506-511. Epub 2016 Nov 15. PMID: 27896253 Free PMC Article</br>10:Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis. Takeuchi A, Koga K, Miyashita M, Makabe T, Sue F, Harada M, Hirata T, Hirota Y, Fujii T, Osuga Y.Eur J Obstet Gynecol Reprod Biol. 2016 Dec;207:157-161. doi: 10.1016/j.ejogrb.2016.10.053. Epub 2016 Nov 8. PMID: 27865118

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