Dibucaine

• CAT Number: I005156
• CAS Number: 85-79-0
• Molecular Formula: C20H29N3O2
• Molecular Weight: 343.5
• Purity: ≥95%
• Synonyms: NSC 159055
• Target: Sodium Channel
• Solubility: DMSO:35mg/mL
• Storage: Store at -20°C
• IUPAC Name: 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide
• InChI: InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24)
• InChIKey: PUFQVTATUTYEAL-UHFFFAOYSA-N
• SMILES: CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC

Dibucaine (Cat.No:I005156) is a local anesthetic belonging to the amide class. It is commonly used for its numbing effect on the skin and mucous membranes. Dibucaine works by blocking nerve signals, temporarily relieving pain and itching. It is often found in over-the-counter creams and ointments for minor skin irritations and hemorrhoids.

Reference

1:Prolonged Paralysis Following Emergent Cesarean Section with Succinylcholine Despite Normal Dibucaine Number. Ellison M, Grose B, Howell S, Wilson C, Lenz J, Driver R.W V Med J. 2016 Mar-Apr;112(2):44-6. PMID: 27025119 Free Article2:A competitive strategy based on cucurbit[7]uril supramolecular interaction for simple and sensitive detection of dibucaine. Li Y, Li CF, Du LM, Feng JX, Liu HL, Fu YL.Talanta. 2015 Jan;132:653-7. doi: 10.1016/j.talanta.2014.09.005. Epub 2014 Sep 11. PMID: 25476359 3:Selective effect of procaine, tetracaine and dibucaine on gold nanoparticles. Mocanu A, Pasca RD, Tomoaia G, Avranas A, Horovitz O, Tomoaia-Cotisel M.J Nanosci Nanotechnol. 2012 Dec;12(12):8935-9. PMID: 23447941 4:Examining protection from anoxic depolarization by the drugs dibucaine and carbetapentane using whole cell recording from CA1 neurons. White SH, Brisson CD, Andrew RD.J Neurophysiol. 2012 Apr;107(8):2083-95. doi: 10.1152/jn.00701.2011. Epub 2012 Jan 25. PMID: 22279188 Free Article5:Dibucaine mitigates spreading depolarization in human neocortical slices and prevents acute dendritic injury in the ischemic rodent neocortex. Risher WC, Lee MR, Fomitcheva IV, Hess DC, Kirov SA.PLoS One. 2011;6(7):e22351. doi: 10.1371/journal.pone.0022351. Epub 2011 Jul 15. PMID: 21789251 Free PMC Article6:Calpain activator dibucaine induces platelet apoptosis. Zhang W, Liu J, Sun R, Zhao L, Du J, Ruan C, Dai K.Int J Mol Sci. 2011;12(4):2125-37. doi: 10.3390/ijms12042125. Epub 2011 Mar 25. PMID: 21731431 Free PMC Article7:Potent inhibition of anoxic depolarization by the sodium channel blocker dibucaine. Douglas HA, Callaway JK, Sword J, Kirov SA, Andrew RD.J Neurophysiol. 2011 Apr;105(4):1482-94. doi: 10.1152/jn.00817.2010. Epub 2011 Jan 27. PMID: 21273307 Free PMC Article8:Cellular responses associated with dibucaine-induced phospholipidosis. Peropadre A, Fernández Freire P, Herrero O, Pérez Martín JM, Hazen MJ.Chem Res Toxicol. 2011 Feb 18;24(2):185-92. doi: 10.1021/tx100262c. Epub 2011 Jan 24. PMID: 21261262 9:Preparation and evaluation of bioadhesive dibucaine gels for enhanced local anesthetic action. Kang C, Shin SC.Arch Pharm Res. 2010 Aug;33(8):1277-83. doi: 10.1007/s12272-010-0819-8. Epub 2010 Aug 28. PMID: 20803132 10:Dibucaine toxicosis in a dog. Hanzlicek AS, Van der Merwe D.J Med Toxicol. 2010 Mar;6(1):44-9. doi: 10.1007/s13181-010-0036-3. PMID: 20224995 Free PMC Article