Diatrizoic acid

• CAT Number: I000636
• CAS Number: 117-96-4
• Molecular Formula: C11H9I3N2O4
• Molecular Weight: 613.91
• Purity: ≥95%
• Solubility: DMSO:40mg/mL
• Storage: Store at -20℃
• IUPAC Name: 3,5-diacetamido-2,4,6-triiodobenzoic acid
• InChI: InChI=1S/C11H9I3N2O4/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18/h1-2H3,(H,15,17)(H,16,18)(H,19,20)
• InChIKey: YVPYQUNUQOZFHG-UHFFFAOYSA-N
• SMILES: CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)NC(=O)C)I

Diatrizoic acid (Cat.No:I000636) is a radiopaque contrast agent used in medical imaging procedures, such as X-rays and CT scans. It enhances the visibility of blood vessels, organs, and tissues, aiding in the diagnosis of various medical conditions. Diatrizoic acid is administered orally or intravenously under medical supervision.

Reference

1:The effect of aspirated barium sulfate, iodixanol, and diatrizoic acid on survival and lung injury in a lagomorph model. Siddiqui MT, Litts JK, Cheney DM, Kuhn MA, Nativ-Zeltzer N, Belafsky PC.Laryngoscope. 2017 May;127(5):E148-E152. doi: 10.1002/lary.26494. Epub 2017 Feb 24. PMID: 28233902 2:Elimination of radiocontrast agent diatrizoic acid by photo-Fenton process and enhanced treatment by coupling with electro-Fenton process. Bocos E, Oturan N, Pazos M, Sanromán MÁ, Oturan MA.Environ Sci Pollut Res Int. 2016 Oct;23(19):19134-44. doi: 10.1007/s11356-016-7054-x. Epub 2016 Jun 28. PMID: 27349786 3:Insights into the crystallisation process from anhydrous, hydrated and solvated crystal forms of diatrizoic acid. Fucke K, McIntyre GJ, Lemée-Cailleau MH, Wilkinson C, Edwards AJ, Howard JA, Steed JW.Chemistry. 2015 Jan 12;21(3):1036-47. doi: 10.1002/chem.201404693. Epub 2014 Nov 4. PMID: 25370384 4:Qualitative environmental risk assessment of photolytic transformation products of iodinated X-ray contrast agent diatrizoic acid. Rastogi T, Leder C, Kümmerer K.Sci Total Environ. 2014 Jun 1;482-483:378-88. doi: 10.1016/j.scitotenv.2014.02.139. Epub 2014 Mar 22. PMID: 24662206 5:Overcoming the solvation shell during the crystallisation of diatrizoic acid from dimethylsulfoxide. Fucke K, Howard JA, Steed JW.Chem Commun (Camb). 2012 Dec 25;48(99):12065-7. doi: 10.1039/c2cc35995b. Epub 2012 Nov 8. PMID: 23139933 6:Facile formation of dendrimer-stabilized gold nanoparticles modified with diatrizoic acid for enhanced computed tomography imaging applications. Peng C, Li K, Cao X, Xiao T, Hou W, Zheng L, Guo R, Shen M, Zhang G, Shi X.Nanoscale. 2012 Nov 7;4(21):6768-78. doi: 10.1039/c2nr31687k. Epub 2012 Sep 26. PMID: 23010987 7:A new water···Na+ coordination motif in an unexpected diatrizoic acid disodium salt crystal form. Fucke K, Peach MJ, Howard JA, Steed JW.Chem Commun (Camb). 2012 Oct 11;48(79):9822-4. doi: 10.1039/c2cc32766j. PMID: 22933041 8:Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. El-Gendy N, Aillon KL, Berkland C.Int J Pharm. 2010 May 31;391(1-2):305-12. doi: 10.1016/j.ijpharm.2010.03.009. Epub 2010 Mar 7. PMID: 20214960 Free PMC Article9:Biodegradability of the X-ray contrast compound diatrizoic acid, identification of aerobic degradation products and effects against sewage sludge micro-organisms. Haiss A, Kümmerer K.Chemosphere. 2006 Jan;62(2):294-302. Epub 2005 Jul 21. PMID: 16039694 10:The effect of glucose and copper on the stability of diatrizoic acid. Chellquist E, Wheeler S, Strasters J, Wolfe H, Storflor H.PDA J Pharm Sci Technol. 1999 Sep-Oct;53(5):247-51. PMID: 10754720