For research use only. Not for therapeutic Use.
diABZI-C2-NH2（Cat No.:I044676）is a synthetic small-molecule agonist of the STING (stimulator of interferon genes) pathway, designed to activate innate immune responses against tumors and viral infections. By binding to and activating STING, diABZI-C2-NH2 induces robust production of type I interferons and pro-inflammatory cytokines, promoting antigen presentation and cytotoxic T cell responses. It features improved potency, stability, and systemic bioavailability compared to earlier STING agonists. diABZI-C2-NH2 is being explored in preclinical cancer immunotherapy models, showing promise as a systemic agent for enhancing anti-tumor immunity and overcoming immune resistance.
| CAS Number | 2137975-93-8 |
| Synonyms | 1-[4-[5-(2-aminoethylcarbamoyl)-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]benzimidazol-1-yl]butyl]-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]benzimidazole-5-carboxamide |
| Molecular Formula | C36H43N13O4 |
| Purity | ≥95% |
| IUPAC Name | 1-[4-[5-(2-aminoethylcarbamoyl)-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]benzimidazol-1-yl]butyl]-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]benzimidazole-5-carboxamide |
| InChI | InChI=1S/C36H43N13O4/c1-5-48-29(17-21(3)44-48)33(52)42-35-40-25-19-23(31(38)50)9-11-27(25)46(35)15-7-8-16-47-28-12-10-24(32(51)39-14-13-37)20-26(28)41-36(47)43-34(53)30-18-22(4)45-49(30)6-2/h9-12,17-20H,5-8,13-16,37H2,1-4H3,(H2,38,50)(H,39,51)(H,40,42,52)(H,41,43,53) |
| InChIKey | OFHOFLFXGGZWEH-UHFFFAOYSA-N |
| SMILES | CCN1C(=CC(=N1)C)C(=O)NC2=NC3=C(N2CCCCN4C5=C(C=C(C=C5)C(=O)NCCN)N=C4NC(=O)C6=CC(=NN6CC)C)C=CC(=C3)C(=O)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
