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DFMTI

DFMTI

  • CAT Number: I005193
  • CAS Number: 864864-86-8
  • Molecular Formula: C20H18F2N4O
  • Molecular Weight: 368.388
  • Purity: ≥95%
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<p style=/line-height:25px/>DFMTI can completely block the rmGlu1 L757V glutamate response.<br>In vitro: DFMTI can completely block the rmGlu1 L757V glutamate response, although significantly higher concentrations were required to induce blockade.<br>In vivo: DFMTI is efficacious in disrupting prepulse inhibition when dosed orally in rats. DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat, exemplified by DFMTI.</p>

Catalog Number I005193
CAS Number 864864-86-8
Molecular Formula

C20H18F2N4O

Purity 95%
Target mGluR1 Receptors Selective Antagonist
Solubility 10 mM in DMSO
Storage 3 years -20C powder
IUPAC Name 5-[1-(2,4-difluorophenyl)-5-methyltriazol-4-yl]-2-propan-2-yl-3H-isoindol-1-one
InChI InChI=1S/C20H18F2N4O/c1-11(2)25-10-14-8-13(4-6-16(14)20(25)27)19-12(3)26(24-23-19)18-7-5-15(21)9-17(18)22/h4-9,11H,10H2,1-3H3
InChIKey KKZVYGIANGOHBS-UHFFFAOYSA-N
SMILES CC1=C(N=NN1C2=C(C=C(C=C2)F)F)C3=CC4=C(C=C3)C(=O)N(C4)C(C)C
Reference

<p style=/line-height:25px/>
<br>[1]. Cho HP et al. A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors. ACS Chem Neurosci. 2014 Jul 16;5(7):597-610.

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