Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant. However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC<sub>50</sub> = 0.55 μM) and nicotinic receptors (IC<sub>50</sub>s = 0.7-<wbr></wbr>3.9 μM) and blocks receptor-<wbr></wbr>gated and voltage-<wbr></wbr>gated calcium channels (IC<sub>50</sub> = 60 μM) and voltage-<wbr></wbr>gated sodium channels (IC<sub>50</sub> = 78 μM). DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.
| Catalog Number | A000067 |
| CAS Number | 6700-34-1 |
| Synonyms | Dextromethorphan hydrobromide monohydrate |
| Molecular Formula | C18H25NO • HBr [H2O] |
| Purity | 95% |
| Storage | -20°C |
| InChIKey | MKXZASYAUGDDCJ-NJAFHUGGSA-N |
