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Albendazole

Albendazole

  • CAT Number: A001229
  • CAS Number: 54965-21-8
  • Molecular Formula: C12H15N3O2S
  • Molecular Weight: 265.33
  • Purity: ≥95%
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<p>
Albendazole(CAS 54965-21-8), marketed as Albenza among others, is a medication used for the treatment of a variety of parasitic worm infestations. It is useful for giardiasis, trichuriasis, filariasis, neurocysticercosis, hydatid disease, pinworm disease, and ascariasis, among others. It is taken by mouth.&nbsp;<span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;"><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">&nbsp;Albendazole interferes with the reproduction and survival of helminths by inhibiting the formation of microtubules from tubulin. This leads to an impaired uptake of glucose</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">, a depletion of glycogen</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">&nbsp;stores, and results in the worm&#39;s death.</span></span></span></p>

Catalog Number A001229
CAS Number 54965-21-8
Molecular Formula

C12H15N3O2S

Purity 95%
Target Antibiotic
Solubility >8.8mg/mL in DMSO
Storage 3 years -20C powder
IUPAC Name methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate
InChI InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
InChIKey HXHWSAZORRCQMX-UHFFFAOYSA-N
SMILES CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC
Reference

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1:Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer. Ghasemi F, Black M, Vizeacoumar F, Pinto N, Ruicci KM, Son Huu Le CC, Lowerison MR, Leong HS, Yoo J, Fung K, MacNeil D, Palma DA, Winquist E, Mymryk JS, Boutros PC, Datti A, Barrett JW, Nichols AC.Oncotarget. 2017 Apr 20. doi: 10.18632/oncotarget.17292. [Epub ahead of print] PMID: 28488581 Free Article<br />
2:Evaluating the predictability of the in vitro transfer model and in vivo rat studies as a surrogate to investigate the supersaturation and precipitation behaviour of different Albendazole formulations for humans. Ruff A, Holm R, Kostewicz ES.Eur J Pharm Sci. 2017 May 1;105:108-118. doi: 10.1016/j.ejps.2017.04.024. [Epub ahead of print] PMID: 28473227<br />
3:Albendazole responsive disseminated Tubulinosema acridophagus in a patient with chronic lymphocytic leukemia. Connors WJ, Carson JA, Chan WW, Parkins MD.Clin Microbiol Infect. 2017 Apr 8. pii: S1198-743X(17)30202-1. doi: 10.1016/j.cmi.2017.04.002. [Epub ahead of print] No abstract available. PMID: 28400339<br />
4:Effect of 3 years of biannual mass drug administration with albendazole on lymphatic filariasis and soil-transmitted helminth infections: a community-based study in Republic of the Congo. Pion SD, Chesnais CB, Weil GJ, Fischer PU, Missamou F, Boussinesq M.Lancet Infect Dis. 2017 Mar 31. pii: S1473-3099(17)30175-5. doi: 10.1016/S1473-3099(17)30175-5. [Epub ahead of print] PMID: 28372977<br />
5:Exposure of Heligmosomoides polygyrus and Trichuris muris to albendazole, albendazole sulfoxide, mebendazole and oxantel pamoate in&nbsp;vitro and in&nbsp;vivo to elucidate the pathway of drug entry into these gastrointestinal nematodes. Cowan N, Meier C, Neodo A, Keiser J.Int J Parasitol Drugs Drug Resist. 2017 Mar 24;7(2):159-173. doi: 10.1016/j.ijpddr.2017.03.005. [Epub ahead of print] PMID: 28371660 Free PMC Article<br />
6:The effect of three-monthly albendazole treatment on Th2 responses: Differential effects on IgE and IL-5. de Ruiter K, Tahapary DL, Wammes LJ, Wiria AE, Hamid F, van Lieshout L, Smit JWA, Houwing-Duistermaat JJ, Sartono E, Supali T, Yazdanbakhsh M.Parasite Immunol. 2017 Jun;39(6). doi: 10.1111/pim.12428. PMID: 28370210 Free Article<br />
7:Anthelmintic drug albendazole arrests human gastric cancer cells at the mitotic phase and induces apoptosis. Zhang X, Zhao J, Gao X, Pei D, Gao C.Exp Ther Med. 2017 Feb;13(2):595-603. doi: 10.3892/etm.2016.3992. Epub 2016 Dec 22. PMID: 28352336 Free PMC Article<br />
8:Effect of nitazoxanide on albendazole pharmacokinetics in cerebrospinal fluid and plasma in rats. Ruiz-Olmedo MI, Gonz&aacute;lez-Hern&aacute;ndez I, Palomares-Alonso F, Franco-P&eacute;rez J, Gonz&aacute;lez F ML, Jung-Cook H.Saudi Pharm J. 2017 Mar;25(3):413-418. doi: 10.1016/j.jsps.2016.09.005. Epub 2016 Sep 30. PMID: 28344497 Free PMC Article<br />
9:The natural history of cystic echinococcosis in untreated and albendazole-treated patients. Solomon N, Kachani M, Zeyhle E, Macpherson CNL.Acta Trop. 2017 Mar 21;171:52-57. doi: 10.1016/j.actatropica.2017.03.018. [Epub ahead of print] PMID: 28336270<br />
10:Toward novel antiparasitic formulations: Complexes of Albendazole desmotropes and &beta;-cyclodextrin. Chattah AK, Pfund LY, Zoppi A, Longhi MR, Garnero C.Carbohydr Polym. 2017 May 15;164:379-385. doi: 10.1016/j.carbpol.2017.01.098. Epub 2017 Feb 3. PMID: 28325339

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