Dexrazoxane

• CAT Number: I002831
• CAS Number: 24584-09-6
• Molecular Formula: C11H16N4O4
• Molecular Weight: 268.3
• Purity: ≥95%
• Target: Others
• Solubility: DMSO 60 mg/mL; Water 60 mg/mL
• Storage: 2-8°C
• IUPAC Name: 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
• InChI: InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
• InChIKey: BMKDZUISNHGIBY-ZETCQYMHSA-N
• SMILES: CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2

Dexrazoxane（Cat No.:I002831）, also known as ICRF187, is a cardioprotective agent used to mitigate the potential cardiotoxic effects of certain chemotherapeutic drugs, particularly anthracyclines like doxorubicin. It functions by chelating iron and preventing its interaction with anthracyclines, thereby reducing the formation of reactive oxygen species and inhibiting oxidative damage to cardiac cells. Dexrazoxane has been shown to reduce the incidence and severity of anthracycline-induced cardiotoxicity, making it a valuable addition to cancer treatment regimens where cardioprotection is a concern.

Reference

1:Dexrazoxane for cardioprotection in older adults with acute myeloid leukemia. Vachhani P, Shin S, Baron J, Thompson JE, Wetzler M, Griffiths EA, Ontiveros EP, Spangenthal EJ, Wang ES.Leuk Res Rep. 2017 Apr 14;7:36-39. doi: 10.1016/j.lrr.2017.04.001. eCollection 2017. PMID: 28462084 Free PMC Article2:Administration of Dexrazoxane Improves Cardiac Indices in Children and Young Adults With Acute Myeloid Leukemia (AML) While Maintaining Survival Outcomes. Schloemer NJ, Brickler M, Hoffmann R, Pan A, Simpson P, McFadden V, Block J, Tower RL 2nd, Burke MJ.J Pediatr Hematol Oncol. 2017 Apr 27. doi: 10.1097/MPH.0000000000000838. [Epub ahead of print] PMID: 28452856 3:Cardioprotective Effect of Dexrazoxane in Patients with HER2-Positive Breast Cancer Who Receive Anthracycline Based Adjuvant Chemotherapy Followed by Trastuzumab. Kim IH, Lee JE, Youn HJ, Song BJ, Chae BJ.J Breast Cancer. 2017 Mar;20(1):82-90. doi: 10.4048/jbc.2017.20.1.82. Epub 2017 Mar 24. PMID: 28382098 Free PMC Article4:Protective Effects of Dexrazoxane against Doxorubicin-Induced Cardiotoxicity: A Metabolomic Study. QuanJun Y, GenJin Y, LiLi W, YongLong H, Yan H, Jie L, JinLu H, Jin L, Run G, Cheng G.PLoS One. 2017 Jan 10;12(1):e0169567. doi: 10.1371/journal.pone.0169567. eCollection 2017. PMID: 28072830 Free PMC Article5:[Effectiveness of Dexrazoxane for Extravasation of Anthracycline Antitumor Antibiotics – Reporting Measures Developed against Extravasation in the Hospital]. Kawamoto S, Shirahata T, Katori T, Izumo T, Kadono H, Fujita H, Okamoto R.Gan To Kagaku Ryoho. 2016 Dec;43(13):2517-2521. Japanese. PMID: 28028257 6:Dexrazoxane Shows No Protective Effect in the Acute Phase of Reperfusion during Myocardial Infarction in Pigs. Kamat P, Vandenberghe S, Christen S, Bongoni AK, Meier B, Rieben R, Khattab AA.PLoS One. 2016 Dec 21;11(12):e0168541. doi: 10.1371/journal.pone.0168541. eCollection 2016. PMID: 28002439 Free PMC Article7:Dexrazoxane improves cardiac autonomic function in epirubicin-treated breast cancer patients with type 2 diabetes. Sun F, Shi J, Geng C.Medicine (Baltimore). 2016 Nov;95(44):e5228. PMID: 27858873 Free Article8:Correction: Utility of Dexrazoxane for the Attenuation of Epirubicin-Induced Genetic Alterations in Mouse Germ Cells. Attia SM, Ahmad SF, Ansari MA, Nadeem A, Al-Shabanah OA, Al-Harbi MM, Bakheet SA.PLoS One. 2016 Oct 27;11(10):e0165854. doi: 10.1371/journal.pone.0165854. eCollection 2016. PMID: 27788265 Free PMC Article9:Utility of Dexrazoxane for the Attenuation of Epirubicin-Induced Genetic Alterations in Mouse Germ Cells. Attia SM, Ahmad SF, Ansaria MA, Nadeem A, Al-Shabanah OA, Al-Harbi MM, Bakheet SA.PLoS One. 2016 Sep 30;11(9):e0163703. doi: 10.1371/journal.pone.0163703. eCollection 2016. Erratum in: PLoS One. 2016 Oct 27;11(10 ):e0165854. PMID: 27690233 Free PMC Article10:Interface-free capillary electrophoresis-mass spectrometry system with nanospray ionization-Analysis of dexrazoxane in blood plasma. Tycova A, Vido M, Kovarikova P, Foret F.J Chromatogr A. 2016 Sep 30;1466:173-9. doi: 10.1016/j.chroma.2016.08.042. Epub 2016 Aug 23. PMID: 27613146