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Dexamethasone Phosphate

Dexamethasone Phosphate

  • CAT Number: R054237
  • CAS Number: 312-93-6
  • Molecular Formula: C22H30FO8P
  • Molecular Weight: 472.446
  • Purity: ≥95%
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<p>
<span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">Dexamethasone Phosphate (CAS&nbsp;312-93-6) is a&nbsp;pro-drug of Dexamethasone, an anti-inflammatory glucocorticoid. It was found that liposomal DXM-P inhibited both chronic inflammation and joint destruction, whereas free DXM-P failed to prevent joint destruction.</span></span></span></p>

Catalog Number R054237
CAS Number 312-93-6
Molecular Formula

C22H30FO8P

Purity 95%
Storage -20°C
IUPAC Name [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] dihydrogen phosphate
InChI InChI=1S/C22H30FO8P/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30)/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChIKey VQODGRNSFPNSQE-CXSFZGCWSA-N
SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)(O)O)O)C)O)F)C
Reference

<p>
<span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">1.Kodelja, Vitam, et al. &quot;Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1&alpha; with a Th2-associated expression pattern.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">The Journal of Immunology</i>&nbsp;160.3 (1998): 1411-1418.<br />
2.Metselaar, Josbert M., et al. &quot;Complete remission of experimental arthritis by joint targeting of glucocorticoids with long‐circulating liposomes.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Arthritis &amp; Rheumatism: Official Journal of the American College of Rheumatology</i>&nbsp;48.7 (2003): 2059-2066.<br />
3.Buttgereit, Frank, et al. &quot;Glucocorticoids in the treatment of rheumatic diseases: an update on the mechanisms of action.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Arthritis &amp; rheumatism</i>&nbsp;50.11 (2004): 3408-3417.<br />
4.Martinez, Fernando Oneissi, et al. &quot;Macrophage activation and polarization.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Front Biosci</i>&nbsp;13.1 (2008): 453-461.</span></span></span></p>

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