Desoximetasone

• CAT Number: I003409
• CAS Number: 382-67-2
• Molecular Formula: C22H29FO4
• Molecular Weight: 376.46
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C

Desoximetasone(Topicort) is a medication belonging to the family of medications known as topical corticosteroids; is used for the relief of various skin conditions, including rashes.IC50 value:Target:When using desoximetasone, some of the medication may be absorbed through the skin and into the bloodstream. Too much absorption can lead to unwanted side effects elsewhere in the body. To keep this problem to a minimum, avoid using large amounts of desoximetasone over large areas, do not use it for extended periods of time, and do not cover it with airtight dressings such as plastic wrap or adhesive bandages unless specifically told to by your doctor.[1] Children may absorb more medication than adults do. Desoximetasone is for use only on the skin and should be kept out of the eyes.

Reference

1:Topical 0.25% Desoximetasone Spray Efficacy for Moderate to Severe Plaque Psoriasis: A Randomized Clinical Trial. Saleem MD, Negus D, Feldman SR.J Dermatolog Treat. 2017 May 13:1-14. doi: 10.1080/09546634.2017.1331027. [Epub ahead of print] PMID: 28504031 2:Desoximetasone 0.25% spray, adrenal suppression and efficacy, in extensive plaque psoriasis. Saleem MD, Feldman SR.J Dermatolog Treat. 2017 May 12:1-11. doi: 10.1080/09546634.2017.1329508. [Epub ahead of print] PMID: 28494626 3:Desoximetasone 0.25% Spray for the Relief of Scaling in Adults With Plaque Psoriasis. Keegan BR.J Drugs Dermatol. 2015 Aug;14(8):835-40. PMID: 26267727 4:Clinical study results of desoximetasone spray, 0.25% in moderate to severe plaque psoriasis. Kircik L, Lebwohl MG, Del Rosso JQ, Bagel J, Stein Gold L, Weiss JS.J Drugs Dermatol. 2013 Dec;12(12):1404-10. PMID: 24301242 5:[Evaluation of effect of local administration of desoximetasone and ditranol in psoriatic lesion byapplying 20 MHz ultrasound]. Stojković T, Binić I, Tiodorović J.Med Pregl. 2012 Sep-Oct;65(9-10):368-72. Serbian. PMID: 23214328 6:Activity of different desoximetasone preparations compared to other topical corticosteroids in the vasoconstriction assay. Borelli C, Gassmueller J, Fluhr JW, Nietsch KH, Schinzel S, Korting HC.Skin Pharmacol Physiol. 2008;21(3):181-7. doi: 10.1159/000131082. Epub 2008 Jun 3. PMID: 18523415 7:Desoximetasone 0.25% and tacrolimus 0.1% ointments versus tacrolimus alone in the treatment of atopic dermatitis. Hebert AA, Koo J, Fowler J, Berman B, Rosenberg C, Levitt J.Cutis. 2006 Nov;78(5):357-63. PMID: 17186796 8:Cross-reactions to desoximetasone and mometasone furoate in a patient with multiple topical corticosteroid allergies. Donovan JC, Dekoven JG.Dermatitis. 2006 Sep;17(3):147-51. PMID: 16956468 9:Compatibility of desoximetasone and tacrolimus. Levitt J, Feldman T, Riss I, Leung OT.J Drugs Dermatol. 2003 Dec;2(6):640-2. PMID: 14711143 10:Randomized double-blind placebo-controlled trial in the treatment of alopecia areata with 0.25% desoximetasone cream. Charuwichitratana S, Wattanakrai P, Tanrattanakorn S.Arch Dermatol. 2000 Oct;136(10):1276-7. No abstract available. PMID: 11030789