Deslorelin

• CAT Number: I004154
• CAS Number: 57773-65-6
• Molecular Formula: C64H83N17O12
• Molecular Weight: 1282.45
• Purity: ≥95%
• Synonyms: Somagard; D-Trp LHRH-PEA; Bachem 9022
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: 3 years -20C powder
• IUPAC Name: (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
• InChI: InChI=1S/C64H83N17O12/c1-4-68-62(92)53-16-10-24-81(53)63(93)46(15-9-23-69-64(65)66)74-56(86)47(25-35(2)3)75-58(88)49(27-37-30-70-43-13-7-5-11-41(37)43)77-57(87)48(26-36-17-19-40(83)20-18-36)76-61(91)52(33-82)80-59(89)50(28-38-31-71-44-14-8-6-12-42(38)44)78-60(90)51(29-39-32-67-34-72-39)79-55(85)45-21-22-54(84)73-45/h5-8,11-14,17-20,30-32,34-35,45-53,70-71,82-83H,4,9-10,15-16,21-29,33H2,1-3H3,(H,67,72)(H,68,92)(H,73,84)(H,74,86)(H,75,88)(H,76,91)(H,77,87)(H,78,90)(H,79,85)(H,80,89)(H4,65,66,69)/t45-,46-,47-,48-,49+,50-,51-,52-,53-/m0/s1
• InChIKey: GJKXGJCSJWBJEZ-XRSSZCMZSA-N
• SMILES: CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8

Deslorelin(CAT: I004154) is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH) that is used as a veterinary medicine for the treatment of various reproductive disorders in animals. GnRH is a hormone that plays a key role in regulating the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland, which in turn control the production of sex hormones such as testosterone and estrogen. By acting as a potent agonist of GnRH receptors, Deslorelin can induce a temporary suppression of gonadal function, which is useful in the treatment of conditions such as ovarian cysts, uterine fibroids, and certain forms of cancer. Deslorelin is typically administered as an implant or injection and can have side effects such as local irritation, lethargy, and changes in behavior.

Overview of Clinical Research

Deslorelin is a gonadotropin releasing hormone stimulant. It has not been granted for the orphan drug status.

Reference

[1]. Lucas X. Clinical use of deslorelin (GnRH agonist) in companion animals: a review. Reprod Domest Anim. 2014 Oct;
[2]. Bujok J et al. Influence of ovariohysterectomy and deslorelin acetate on the spontaneous activity of the rabbit urinary bladder in vitro. Theriogenology. 2016 Feb;85(3):441-6.