Desloratadine

• CAT Number: A000328
• CAS Number: 100643-71-8
• Molecular Formula: C19H19ClN2
• Molecular Weight: 310.82
• Purity: ≥95%
• Synonyms: CH-34117, NSC 675447
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• IUPAC Name: 13-chloro-2-piperidin-4-ylidene-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene
• InChI: InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
• InChIKey: JAUOIFJMECXRGI-UHFFFAOYSA-N
• SMILES: C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4

Desloratadine (Cat No.: A000328) is a non-sedating, long-acting antihistamine used to relieve symptoms of allergic conditions such as hay fever, urticaria, and seasonal allergic rhinitis. As the active metabolite of loratadine, it selectively blocks peripheral histamine H1 receptors, preventing allergic responses without crossing the blood-brain barrier significantly—thus minimizing drowsiness. Desloratadine provides rapid and sustained relief from sneezing, runny nose, itching, and hives. It is available in tablets, syrups, and orally disintegrating forms, and is well-tolerated in both adults and children.

Overview of Clinical Research

Desloratadine is a Histamine H1 receptor antagonist. It has been granted for the new molecular entity.

Reference

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