Pralidoxime Chloride

• CAT Number: A000063
• CAS Number: 51-15-0
• Molecular Formula: C7H9ClN2O
• Molecular Weight: 172.61
• Purity: ≥95%
• Storage: Room Temperature
• IUPAC Name: (NE)-N-[(1-methylpyridin-1-ium-2-yl)methylidene]hydroxylamine;chloride
• InChI: InChI=1S/C7H8N2O.ClH/c1-9-5-3-2-4-7(9)6-8-10;/h2-6H,1H3;1H
• InChIKey: HIGSLXSBYYMVKI-UHFFFAOYSA-N
• SMILES: C[N+]1=CC=CC=C1C=NO.[Cl-]

Pralidoxime chloride（Cat No.:A000063）, is a pharmaceutical compound used as an antidote for organophosphate and carbamate pesticide poisoning. It works by reactivating acetylcholinesterase, an enzyme that helps regulate nerve signals, which is inhibited by these toxins. Pralidoxime chloride can reverse the toxic effects of these chemicals, such as muscle weakness and respiratory distress, by restoring proper nerve function. It is often administered in combination with other treatments, like atropine, to manage pesticide poisoning.

Reference

1: Zheng Q, Chen Y, Fan K, Wu J, Ying Y. Exploring pralidoxime chloride as a
universal electrochemical probe for organophosphorus pesticides detection. Anal
Chim Acta. 2017 Aug 22;982:78-83. doi: 10.1016/j.aca.2017.06.006. Epub 2017 Jun
17. PubMed PMID: 28734368.

2: Uwaydah NI, Hoskins SL, Bruttig SP, Farrar H, Copper NC, Deyo DJ, Dubick MA,
Kramer GC. Intramuscular versus Intraosseous Delivery of Nerve Agent Antidote
Pralidoxime Chloride in Swine. Prehosp Emerg Care. 2016 Jul-Aug;20(4):485-92.
doi: 10.3109/10903127.2014.942479. Epub 2016 May 9. PubMed PMID: 27158860.

3: Liu HX, Liu CF, Yang WH. Clinical study of continuous micropump infusion of
atropine and pralidoxime chloride for treatment of severe acute organophosphorus
insecticide poisoning. J Chin Med Assoc. 2015 Dec;78(12):709-13. doi:
10.1016/j.jcma.2015.08.006. Epub 2015 Oct 3. PubMed PMID: 26441220.

4: Banerjee S, Chattopadhyay P, Ghosh A, Bhatnagar A, Veer V. Pharmacokinetic and
biodistribution study of eserine and pralidoxime chloride in rabbits following a
single application of a transdermal patch. Eur J Drug Metab Pharmacokinet. 2016
Jun;41(3):219-30. doi: 10.1007/s13318-014-0250-5. Epub 2014 Dec 30. PubMed PMID:
25547639.

5: Banerjee S, Chattopadhyay P, Ghosh A, Pathak MP, Gogoi J, Veer V. Protection
by a transdermal patch containing eserine and pralidoxime chloride for
prophylaxis against (±)-Anatoxin A poisoning in rats. Eur J Pharm Sci. 2014 Jun
2;56:28-36. doi: 10.1016/j.ejps.2014.01.013. Epub 2014 Feb 14. PubMed PMID:
24530375.

6: Lucyk S, Vilensky D, Fok PT, Nelson LS. Reactivation of plasma
butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class
II toxicity organophosphorus insecticides. Toxicol Sci. 2014 Apr;138(2):482. doi:
10.1093/toxsci/kft337. Epub 2014 Jan 2. PubMed PMID: 24385419.

7: Connors NJ, Weber BJ, Hoffman RS. Regarding /Repeated pulse intramuscular
injection of pralidoxime chloride in severe acute organophosphorus pesticide
poisoning/. Am J Emerg Med. 2013 Dec;31(12):1711-2. doi:
10.1016/j.ajem.2013.08.052. Epub 2013 Oct 1. PubMed PMID: 24091197.

8: Konickx LA, Worek F, Jayamanne S, Thiermann H, Buckley NA, Eddleston M.
Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients
poisoned by WHO class II toxicity organophosphorus insecticides. Toxicol Sci.
2013 Dec;136(2):274-83. doi: 10.1093/toxsci/kft217. Epub 2013 Sep 19. PubMed
PMID: 24052565; PubMed Central PMCID: PMC3858199.

9: Tang X, Wang R, Xie H, Hu J, Zhao W. Repeated pulse intramuscular injection of
pralidoxime chloride in severe acute organophosphorus pesticide poisoning. Am J
Emerg Med. 2013 Jun;31(6):946-9. doi: 10.1016/j.ajem.2013.03.012. Epub 2013 May
14. PubMed PMID: 23680326.

10: Banerjee S, Chattopadhyay P, Ghosh A, Kaity S, Veer V. Development and
validation of a reverse phase liquid chromatography method for the simultaneous
quantification of eserine and pralidoxime chloride in drugs-in-adhesive matrix
type transdermal patches. Drug Res (Stuttg). 2013 Sep;63(9):450-6. doi:
10.1055/s-0033-1343471. Epub 2013 Apr 30. PubMed PMID: 23633237.