Desbutyl Lumefantrine

• CAT Number: R043373
• CAS Number: 355841-11-1
• Molecular Formula: C26H24Cl3NO
• Molecular Weight: 472.83
• Purity: ≥95%
• Synonyms: 2-(butylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol
• InChI: InChI=1S/C26H24Cl3NO/c1-2-3-10-30-15-25(31)24-14-19(29)13-23-21(11-16-4-6-17(27)7-5-16)22-12-18(28)8-9-20(22)26(23)24/h4-9,11-14,25,30-31H,2-3,10,15H2,1H3/b21-11-
• InChIKey: YLBUTQNEBVPTES-NHDPSOOVSA-N
• SMILES: CCCCNCC(C1=CC(=CC2=C1C3=C(C2=CC4=CC=C(C=C4)Cl)C=C(C=C3)Cl)Cl)O

Desbutyl Lumefantrine(CAT: R043373) is an active metabolite of lumefantrine, a long-acting aryl amino alcohol antimalarial agent commonly used in combination therapies against Plasmodium falciparum. Formed via hepatic metabolism, Desbutyl Lumefantrine contributes to the pharmacological activity of lumefantrine-based regimens, exhibiting potent antiplasmodial effects. It functions by interfering with heme detoxification pathways in the parasite, leading to parasite death. As a reference standard, it is valuable in drug metabolism, pharmacokinetic, and bioanalytical studies. Desbutyl Lumefantrine is particularly useful in malaria research, therapeutic drug monitoring, and investigations of drug resistance mechanisms in Plasmodium species.